Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice

Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice

Histone acetylation has been shown to play a crucial role in memory formation, and histone deacetylase (HDAC) inhibitor sodium butyrate (NaB) has been demonstrated to improve memory performance and rescue the neurodegeneration of several Alzheimer’s Disease (AD) mouse models. The forebrain presenili...

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Bibliographic Details
Main Authors: Ting Cao, Xiaojuan Zhou, Xianjie Zheng, Yue Cui, Joe Z. Tsien, Chunxia Li, Huimin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
histone deacetylase inhibitor
fear memory
tau hyperphosphorylation
neuroinflammation
histone acetylation dysregulation
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2018.00137/full

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http://journal.frontiersin.org/article/10.3389/fnagi.2018.00137/full

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