Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery

Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery

Protein kinases and GTPases are the two major molecular switches that regulate much of biology, and both of these domains are embedded within the large multi-domain Leucine-Rich Repeat Kinase 2 (LRRK2). Mutations in LRRK2 are the most common cause of familial Parkinson’s disease (PD) and are also im...

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Bibliographic Details
Main Authors: Susan S. Taylor, Pallavi Kaila-Sharma, Jui-Hung Weng, Phillip Aoto, Sven H. Schmidt, Stefan Knapp, Sebastian Mathea, Friedrich W. Herberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
protein kinase (PK)
GTPase
allostery
hydrophobic cores
Walker motifs
leucin rich repeat kinase 2 (LRRK2)
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.538219/full

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https://www.frontiersin.org/article/10.3389/fnmol.2020.538219/full

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