Studies on tissue distribution of scutellarin and methyl polyethylene glycol (mPEG)-scutellarin prodrug in mice

This study was to determine tissue distribution and pharmacokinetics of mPEG-scutellarin prodrug (7e), a chemical entity previously shown to have a beneficial effect in cerebral ischemia/reperfusion (I/R) injury. After injecting scutellarin or prodrug 7e, the concentrations of scutellarin and 7e in...

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Bibliographic Details
Main Authors: Juan Lu, Xia Zhan, Qingfei Liu, Xi Chen, Xinge Zhao, Yiming Wang, Guoan Luo
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S221138351200055X