T4SS-dependent TLR5 activation by Helicobacter pylori infection

Toll-like receptor TLR5 recognizes a domain, D1, that is present in flagellins of several pathogenic bacteria but not in Helicobacter pylori. Here, the authors show that TLR5 can be activated independently of flagellin by a component of the H. pylori type IV secretion system that contains a D1-like...

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Bibliographic Details
Main Authors: Suneesh Kumar Pachathundikandi, Nicole Tegtmeyer, Isabelle Catherine Arnold, Judith Lind, Matthias Neddermann, Christina Falkeis-Veits, Sujay Chattopadhyay, Mark Brönstrup, Werner Tegge, Minsun Hong, Heinrich Sticht, Michael Vieth, Anne Müller, Steffen Backert
Format: Article
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13506-6