T4SS-dependent TLR5 activation by Helicobacter pylori infection

T4SS-dependent TLR5 activation by Helicobacter pylori infection

Toll-like receptor TLR5 recognizes a domain, D1, that is present in flagellins of several pathogenic bacteria but not in Helicobacter pylori. Here, the authors show that TLR5 can be activated independently of flagellin by a component of the H. pylori type IV secretion system that contains a D1-like...

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Main Authors: Suneesh Kumar Pachathundikandi, Nicole Tegtmeyer, Isabelle Catherine Arnold, Judith Lind, Matthias Neddermann, Christina Falkeis-Veits, Sujay Chattopadhyay, Mark Brönstrup, Werner Tegge, Minsun Hong, Heinrich Sticht, Michael Vieth, Anne Müller, Steffen Backert
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13506-6
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spelling doaj-4795a418a17340b78d3418bb043e25902021-05-11T12:26:24ZengNature Publishing GroupNature Communications2041-17232019-12-0110111110.1038/s41467-019-13506-6T4SS-dependent TLR5 activation by Helicobacter pylori infectionSuneesh Kumar Pachathundikandi0Nicole Tegtmeyer1Isabelle Catherine Arnold2Judith Lind3Matthias Neddermann4Christina Falkeis-Veits5Sujay Chattopadhyay6Mark Brönstrup7Werner Tegge8Minsun Hong9Heinrich Sticht10Michael Vieth11Anne Müller12Steffen Backert13Department of Biology, Division of Microbiology, Friedrich Alexander University Erlangen-NurembergDepartment of Biology, Division of Microbiology, Friedrich Alexander University Erlangen-NurembergInstitute of Molecular Cancer Research, University of ZurichDepartment of Biology, Division of Microbiology, Friedrich Alexander University Erlangen-NurembergDepartment of Biology, Division of Microbiology, Friedrich Alexander University Erlangen-NurembergInstitute for Pathology, Klinikum BayreuthJIS Institute of Advanced Studies and Research, JIS UniversityDepartment of Chemical Biology, Helmholtz Centre for Infection ResearchDepartment of Chemical Biology, Helmholtz Centre for Infection ResearchDivision of Biological Science and Technology, Yonsei UniversityInstitute of Biochemistry, Division of Bioinformatics, Friedrich Alexander University Erlangen-NurembergInstitute for Pathology, Klinikum BayreuthInstitute of Molecular Cancer Research, University of ZurichDepartment of Biology, Division of Microbiology, Friedrich Alexander University Erlangen-NurembergToll-like receptor TLR5 recognizes a domain, D1, that is present in flagellins of several pathogenic bacteria but not in Helicobacter pylori. Here, the authors show that TLR5 can be activated independently of flagellin by a component of the H. pylori type IV secretion system that contains a D1-like motif.https://doi.org/10.1038/s41467-019-13506-6
collection DOAJ
language English
format Article
sources DOAJ
author Suneesh Kumar Pachathundikandi
Nicole Tegtmeyer
Isabelle Catherine Arnold
Judith Lind
Matthias Neddermann
Christina Falkeis-Veits
Sujay Chattopadhyay
Mark Brönstrup
Werner Tegge
Minsun Hong
Heinrich Sticht
Michael Vieth
Anne Müller
Steffen Backert
spellingShingle Suneesh Kumar Pachathundikandi
Nicole Tegtmeyer
Isabelle Catherine Arnold
Judith Lind
Matthias Neddermann
Christina Falkeis-Veits
Sujay Chattopadhyay
Mark Brönstrup
Werner Tegge
Minsun Hong
Heinrich Sticht
Michael Vieth
Anne Müller
Steffen Backert
T4SS-dependent TLR5 activation by Helicobacter pylori infection
Nature Communications
author_facet Suneesh Kumar Pachathundikandi
Nicole Tegtmeyer
Isabelle Catherine Arnold
Judith Lind
Matthias Neddermann
Christina Falkeis-Veits
Sujay Chattopadhyay
Mark Brönstrup
Werner Tegge
Minsun Hong
Heinrich Sticht
Michael Vieth
Anne Müller
Steffen Backert
author_sort Suneesh Kumar Pachathundikandi
title T4SS-dependent TLR5 activation by Helicobacter pylori infection
title_short T4SS-dependent TLR5 activation by Helicobacter pylori infection
title_full T4SS-dependent TLR5 activation by Helicobacter pylori infection
title_fullStr T4SS-dependent TLR5 activation by Helicobacter pylori infection
title_full_unstemmed T4SS-dependent TLR5 activation by Helicobacter pylori infection
title_sort t4ss-dependent tlr5 activation by helicobacter pylori infection
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-12-01
description Toll-like receptor TLR5 recognizes a domain, D1, that is present in flagellins of several pathogenic bacteria but not in Helicobacter pylori. Here, the authors show that TLR5 can be activated independently of flagellin by a component of the H. pylori type IV secretion system that contains a D1-like motif.
url https://doi.org/10.1038/s41467-019-13506-6
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