BMSC-derived extracellular vesicles intervened the pathogenic changes of scleroderma in mice through miRNAs

BMSC-derived extracellular vesicles intervened the pathogenic changes of scleroderma in mice through miRNAs

Abstract Background Systemic sclerosis (SSc) is a disease that features severe fibrosis of the skin and lacks effective therapy. Bone marrow mesenchymal stem cell (BMSC)-derived extracellular vesicles (EVs) are potential stem cell-based tools for the treatment of SSc. Methods BMSCs were isolated fro...

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Bibliographic Details
Main Authors: Jiahui Jin, Qingjian Ou, Zhe Wang, Haibin Tian, Jing-Ying Xu, Furong Gao, Shuqin Hu, Jie Chen, Juan Wang, Jieping Zhang, Lixia Lu, Caixia Jin, Guo-Tong Xu, Jingjun Zhao
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Stem Cell Research & Therapy
Subjects:
Scleroderma
Fibrosis
Bone marrow mesenchymal stem cell
Extracellular vesicles
Online Access:https://doi.org/10.1186/s13287-021-02400-y

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