Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca(2+) Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity.

Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca(2+) Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity.

Some of insulin's functions, including glucose/lipid metabolism, satiety and neuroprotection, involve the alteration of brain activities. Insulin could signal to the brain via penetrating through the blood-brain barrier and acting on the vagal afferents, while the latter remains unproved. This...

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Bibliographic Details
Main Authors: Yusaku Iwasaki, Kenju Shimomura, Daisuke Kohno, Katsuya Dezaki, Enkh-Amar Ayush, Hajime Nakabayashi, Naoto Kubota, Takashi Kadowaki, Masafumi Kakei, Masanori Nakata, Toshihiko Yada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3693960?pdf=render

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http://europepmc.org/articles/PMC3693960?pdf=render

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