Estimation of interleukin-18 in the gingival crevicular fluid and serum of Bengali population with periodontal health and disease

Context: Host's immune response elicits cytokines in response to bacterial challenge. We explore role of one such cytokine interleukin-18 (IL-18) in periodontal health and disease. Aims: IL-18 is a pro-inflammatory and tumor suppressive cytokine. Dental literatures suggest that IL-18 might have...

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Main Authors: Vineet Nair, Prasanta Bandyopadhyay, Debabrata Kundu, Satadal Das
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Journal of Indian Society of Periodontology
Subjects:
Online Access:http://www.jisponline.com/article.asp?issn=0972-124X;year=2016;volume=20;issue=3;spage=260;epage=264;aulast=Nair
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spelling doaj-47ea0d195ea34298a280be4144e02c222020-11-24T22:34:15ZengWolters Kluwer Medknow PublicationsJournal of Indian Society of Periodontology0972-124X2016-01-0120326026410.4103/0972-124X.183098Estimation of interleukin-18 in the gingival crevicular fluid and serum of Bengali population with periodontal health and diseaseVineet NairPrasanta BandyopadhyayDebabrata KunduSatadal DasContext: Host's immune response elicits cytokines in response to bacterial challenge. We explore role of one such cytokine interleukin-18 (IL-18) in periodontal health and disease. Aims: IL-18 is a pro-inflammatory and tumor suppressive cytokine. Dental literatures suggest that IL-18 might have a role to play in the progression from oral health to periodontal disease. Therefore, this study was undertaken to elucidate the level and role of IL-18 in the gingival crevicular fluid (GCF) and serum of individuals with healthy gingiva, chronic gingivitis, chronic periodontitis, and aggressive periodontitis before and after periodontal therapy. Settings and Design: Eighty individuals chosen for the study were divided into healthy control group (1A), chronic gingivitis (2A), chronic periodontitis (3A), and aggressive periodontitis (4A) with twenty individuals each. Criteria for the division were the subject's gingival index, probing pocket depth, clinical attachment loss, and radiographic evidence of bone loss. Materials and Methods: The individuals underwent treatment (scaling in case of Groups 1A and 2A and scaling and root planing followed by flap surgery in Groups 3A and 4A) to form posttreatment Groups 1B, 2B, 3B, and 4B, respectively. Thus, a total of 160 GCF and 160 serum samples were collected and tested by ELISA.Statistical Analysis Used: Intergroup comparison was done by post hoc Tukey's test. Results: The mean IL-18 concentration was greatest in Group 3A (GCF 144.61 pg/μl, serum 55.12 pg/ml) followed by Group 4A (GCF 98.55 pg/μl, serum 39.06 pg/ml), Group 2A (GCF 22.27 pg/μl, serum 27.73 pg/ml) and lowest (GCF 17.94 pg/μl, serum 11.49 pg/ml) in Group 1A. Posttreatment groups (1B–4B) showed reduction in the mean IL-18 concentration in both GCF and serum. Conclusions: As the inflammation increased, there was a concomitant increase in the level of IL-18 and vice versa following periodontal therapy.http://www.jisponline.com/article.asp?issn=0972-124X;year=2016;volume=20;issue=3;spage=260;epage=264;aulast=NairGingival crevicular fluidgingivitisinterleukinperiodontitisserum
collection DOAJ
language English
format Article
sources DOAJ
author Vineet Nair
Prasanta Bandyopadhyay
Debabrata Kundu
Satadal Das
spellingShingle Vineet Nair
Prasanta Bandyopadhyay
Debabrata Kundu
Satadal Das
Estimation of interleukin-18 in the gingival crevicular fluid and serum of Bengali population with periodontal health and disease
Journal of Indian Society of Periodontology
Gingival crevicular fluid
gingivitis
interleukin
periodontitis
serum
author_facet Vineet Nair
Prasanta Bandyopadhyay
Debabrata Kundu
Satadal Das
author_sort Vineet Nair
title Estimation of interleukin-18 in the gingival crevicular fluid and serum of Bengali population with periodontal health and disease
title_short Estimation of interleukin-18 in the gingival crevicular fluid and serum of Bengali population with periodontal health and disease
title_full Estimation of interleukin-18 in the gingival crevicular fluid and serum of Bengali population with periodontal health and disease
title_fullStr Estimation of interleukin-18 in the gingival crevicular fluid and serum of Bengali population with periodontal health and disease
title_full_unstemmed Estimation of interleukin-18 in the gingival crevicular fluid and serum of Bengali population with periodontal health and disease
title_sort estimation of interleukin-18 in the gingival crevicular fluid and serum of bengali population with periodontal health and disease
publisher Wolters Kluwer Medknow Publications
series Journal of Indian Society of Periodontology
issn 0972-124X
publishDate 2016-01-01
description Context: Host's immune response elicits cytokines in response to bacterial challenge. We explore role of one such cytokine interleukin-18 (IL-18) in periodontal health and disease. Aims: IL-18 is a pro-inflammatory and tumor suppressive cytokine. Dental literatures suggest that IL-18 might have a role to play in the progression from oral health to periodontal disease. Therefore, this study was undertaken to elucidate the level and role of IL-18 in the gingival crevicular fluid (GCF) and serum of individuals with healthy gingiva, chronic gingivitis, chronic periodontitis, and aggressive periodontitis before and after periodontal therapy. Settings and Design: Eighty individuals chosen for the study were divided into healthy control group (1A), chronic gingivitis (2A), chronic periodontitis (3A), and aggressive periodontitis (4A) with twenty individuals each. Criteria for the division were the subject's gingival index, probing pocket depth, clinical attachment loss, and radiographic evidence of bone loss. Materials and Methods: The individuals underwent treatment (scaling in case of Groups 1A and 2A and scaling and root planing followed by flap surgery in Groups 3A and 4A) to form posttreatment Groups 1B, 2B, 3B, and 4B, respectively. Thus, a total of 160 GCF and 160 serum samples were collected and tested by ELISA.Statistical Analysis Used: Intergroup comparison was done by post hoc Tukey's test. Results: The mean IL-18 concentration was greatest in Group 3A (GCF 144.61 pg/μl, serum 55.12 pg/ml) followed by Group 4A (GCF 98.55 pg/μl, serum 39.06 pg/ml), Group 2A (GCF 22.27 pg/μl, serum 27.73 pg/ml) and lowest (GCF 17.94 pg/μl, serum 11.49 pg/ml) in Group 1A. Posttreatment groups (1B–4B) showed reduction in the mean IL-18 concentration in both GCF and serum. Conclusions: As the inflammation increased, there was a concomitant increase in the level of IL-18 and vice versa following periodontal therapy.
topic Gingival crevicular fluid
gingivitis
interleukin
periodontitis
serum
url http://www.jisponline.com/article.asp?issn=0972-124X;year=2016;volume=20;issue=3;spage=260;epage=264;aulast=Nair
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