Mechanistic Basis for In Vivo Therapeutic Efficacy of CK2 Inhibitor CX-4945 in Acute Myeloid Leukemia

Mechanistic Basis for In Vivo Therapeutic Efficacy of CK2 Inhibitor CX-4945 in Acute Myeloid Leukemia

Protein Kinase CK2 (Casein Kinase 2 or CK2) is a constitutively active serine-threonine kinase overactive in human malignancies. Increased expression and activity of CK2 in Acute Myeloid Leukemia (AML) is associated with a poor outcome. CK2 promotes AML cell survival by impinging on multiple oncogen...

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Bibliographic Details
Main Authors: Morgann Klink, Mohammad Atiqur Rahman, Chunhua Song, Pavan Kumar Dhanyamraju, Melanie Ehudin, Yali Ding, Sadie Steffens, Preeti Bhadauria, Soumya Iyer, Cesar Aliaga, Dhimant Desai, Suming Huang, David Claxton, Arati Sharma, Chandrika Gowda
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
protein kinase CK2
acute myeloid leukemia
ikaros
bcl-xl
anti-apoptotic gene
CX-4945
Online Access:https://www.mdpi.com/2072-6694/13/5/1127

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