Inhibition of Mef2a Enhances Neovascularization via Post-transcriptional Regulation of 14q32 MicroRNAs miR-329 and miR-494

Inhibition of Mef2a Enhances Neovascularization via Post-transcriptional Regulation of 14q32 MicroRNAs miR-329 and miR-494

Improving the efficacy of neovascularization is a promising strategy to restore perfusion of ischemic tissues in patients with peripheral arterial disease. The 14q32 microRNA cluster is highly involved in neovascularization. The Mef2a transcription factor has been shown to induce transcription of th...

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Bibliographic Details
Main Authors: Sabine M.J. Welten, Margreet R. de Vries, Erna A.B. Peters, Sudhir Agrawal, Paul H.A. Quax, A. Yaël Nossent
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MEF2A
miR-329
miR-494
14q32
neovascularization
arteriogenesis
angiogenesis
posttranscriptional regulation
RNA binding protein
ischemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117301415

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http://www.sciencedirect.com/science/article/pii/S2162253117301415

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