Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis

Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive injury and reprogramming of the lung epithelium are thought to be critical drivers of disease progression, contributing to fibroblast activation, extracellular matrix remodeling, and subsequently...

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Bibliographic Details
Main Authors: Mareike Lehmann, Lara Buhl, Hani N. Alsafadi, Stephan Klee, Sarah Hermann, Kathrin Mutze, Chiharu Ota, Michael Lindner, Jürgen Behr, Anne Hilgendorff, Darcy E. Wagner, Melanie Königshoff
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Respiratory Research
Subjects:
IPF
Epithelial cells
ATII
Nintedanib
Pirfenidone
ex vivo
Online Access:http://link.springer.com/article/10.1186/s12931-018-0876-y

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http://link.springer.com/article/10.1186/s12931-018-0876-y

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