Integration of Lipidomics and Transcriptomics Reveals Reprogramming of the Lipid Metabolism and Composition in Clear Cell Renal Cell Carcinoma

Integration of Lipidomics and Transcriptomics Reveals Reprogramming of the Lipid Metabolism and Composition in Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma (ccRCC) is fundamentally a metabolic disease. Given the importance of lipids in many cellular processes, in this study we delineated a lipidomic profile of human ccRCC and integrated it with transcriptomic data to connect the variations in cancer lipid metabolism with...

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Bibliographic Details
Main Authors: Giuseppe Lucarelli, Matteo Ferro, Davide Loizzo, Cristina Bianchi, Daniela Terracciano, Francesco Cantiello, Lauren N. Bell, Stefano Battaglia, Camillo Porta, Angela Gernone, Roberto A. Perego, Eugenio Maiorano, Ottavio de Cobelli, Giuseppe Castellano, Leonardo Vincenti, Pasquale Ditonno, Michele Battaglia
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Metabolites
Subjects:
renal cell carcinoma
lipidomics
SCD1
cholesterol
lipids
Online Access:https://www.mdpi.com/2218-1989/10/12/509

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