Mobilization of Nuclear Copper by Green Tea Polyphenol Epicatechin-3-Gallate and Subsequent Prooxidant Breakage of Cellular DNA: Implications for Cancer Chemotherapy

Mobilization of Nuclear Copper by Green Tea Polyphenol Epicatechin-3-Gallate and Subsequent Prooxidant Breakage of Cellular DNA: Implications for Cancer Chemotherapy

Epidemiological as well as experimental evidence exists in support of chemopreventive and anticancer properties of green tea and its constituents. The gallocatechin, epicatechin-3-gallate is a major polyphenol present in green tea, shown responsible for these effects. Plant-derived polyphenolic comp...

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Bibliographic Details
Main Authors: Mohd Farhan, Mohammad Oves, Sandesh Chibber, Sheikh Mumtaz Hadi, Aamir Ahmad
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:International Journal of Molecular Sciences
Subjects:
epicatechin-3-gallate
copper
DNA damage
comet assay
reactive oxygen species
prooxidant
anticancer
Online Access:http://www.mdpi.com/1422-0067/18/1/34

Internet

http://www.mdpi.com/1422-0067/18/1/34

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