Integrated Multi-Omic Analyses of the Genomic Modifications by Gut Microbiome-Derived Metabolites of Epicatechin, 5-(4′-Hydroxyphenyl)-γ-Valerolactone, in TNFalpha-Stimulated Primary Human Brain Microvascular Endothelial Cells

Integrated Multi-Omic Analyses of the Genomic Modifications by Gut Microbiome-Derived Metabolites of Epicatechin, 5-(4′-Hydroxyphenyl)-γ-Valerolactone, in TNFalpha-Stimulated Primary Human Brain Microvascular Endothelial Cells

Cerebral blood vessels are lined with endothelial cells and form the blood-brain barrier. Their dysfunction constitutes a crucial event in the physiopathology of neurodegenerative disorders and cognitive impairment. Epicatechin can improve cognitive functions and lower the risk for Alzheimer’s disea...

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Bibliographic Details
Main Authors: Karla Fabiola Corral-Jara, Saivageethi Nuthikattu, John Rutledge, Amparo Villablanca, Christine Morand, Hagen Schroeter, Dragan Milenkovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Neuroscience
Subjects:
valerolactones
epicatechin
genomics
multi-omics
lncRNA
brain endothelial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.622640/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.622640/full

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