Synthesis of Some Heterocyclic Compounds Containing Tetrahydroisoquinoline Moiety

• Main Authors: Mohammad Al-Iraqi, Ahmad Najem
• Format: Article
• Language: Arabic
• Published: College of Education for Pure Sciences 2013-12-01
• Series: مجلة التربية والعلم
• Subjects: tetrahydroisoquinoline; oxadiazole; thiadiazole; hydrazide; diacylhydrazine; heterocyclic compounds
• Online Access: https://edusj.mosuljournals.com/article_163063_494b030a634f7035800eb6843f9f869b.pdf
• ISSN: 1812-125X; 2664-2530

<strong>ABSTRACT</strong><br /> <strong>      </strong>This research involves synthesis of some five membered heterocyclic compounds using 1,2,3,4-tetrahydroisoquinoline as a synthone. The initial step in this research involves the reaction of 1,2,3,4-tetrahydroisoquinoline with ethyl chloroacetate to form ethyl α-(1,2,3,4-tetrahydroisoquinolin-2-yl) acetate (1), which was converted to the hydrazide (2). This hydrazide was used to prepare some heterocyclic compounds, such as substituted oxadiazoles (7-10, 23) and thiadiazoles (11-14) via preparation of intermediate compounds such as diacylhydrazines (3-6), hydrazones (15-18) and substituted oxadiazoline compounds (19-22) and (24-27). The synthesized compounds were identified on the basis of some physical and IR spectral data.