Zirconia Nanoparticles Induce HeLa Cell Death Through Mitochondrial Apoptosis and Autophagy Pathways Mediated by ROS

Zirconia Nanoparticles Induce HeLa Cell Death Through Mitochondrial Apoptosis and Autophagy Pathways Mediated by ROS

Zirconia nanoparticles (ZrO2 NPs) are commonly used in the field of biomedical materials, but their antitumor activity and mechanism is unclear. Herein, we evaluated the anti-tumor activity of ZrO2 NPs and explored the anti-tumor mechanism. The results of in vitro and in vivo experiments showed that...

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Bibliographic Details
Main Authors: Yinghui Shang, Qinghai Wang, Jian Li, Haiting Liu, Qiangqiang Zhao, Xueyuan Huang, Hang Dong, Wansong Chen, Rong Gui, Xinmin Nie
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Chemistry
Subjects:
anticancer
reactive oxygen species
autophagy
apoptosis
zirconia
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.522708/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.522708/full

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