The Protective Role of Folic Acid and Vitamin E Against Toxical Effects of Valproic Acid on Liver Tissue During Period of Gestation

• Main Authors: Özlem Pamukçu Baran, Ayşe Yıldırım, Murat Akkuş
• Format: Article
• Language: English
• Published: Dicle University Medical School 2004-01-01
• Series: Dicle Medical Journal
• Subjects: Liver; Valproic Acid; Folic Acid; Vitamin E; Hepatotoxicity
• Online Access: http://4181.indexcopernicus.com/fulltxt.php?ICID=887958

Valproic acid is an anticonvulsan drug used in epilepsy. Thehistopathological changes of valproic acid on liver and the protective effectof vitamin E and also folic acid were observed. 24 adult female Wistar Albinorats were used. The first control, the second valproic acid group that wasgiven 300 mg/kg on 8.9. and 10. days of gestation, the third valproic acid+vitamin E group. Vitamin E was given 250mg/kg via nasogastric intubationbefore one hour administration of valproic acid on 8.9.10.days of gestation.The fourth valproic acid+ folic acid group; via valproic acid, folic acid wasgiven 400 microgram ordinarily in drinking water per day. In the liversections of valproic acid group, perivenullar dilatation, swelling of Kuppfercells, microvesicular steatosis and degeneration were observed. In the secondgroup there was moderate degeneration in hepatocytes,necrotic areas insome places, mononuclear cell infiltration. In valproic acid +vitamin E groupnormal-like appearance of the structure of Remark cell lines were observed.Under these source of results, we viewed antioxidants decreased thehepatotoxicity on liver tissue by using folic acid and vitamin E .