Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila

Recent lineage tracing analyses have significantly improved our understanding of immune system development and highlighted the importance of the different hematopoietic waves. The current challenge is to understand whether these waves interact and whether this affects the function of the immune syst...

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Main Authors: Wael Bazzi, Pierre B Cattenoz, Claude Delaporte, Vasanthi Dasari, Rosy Sakr, Yoshihiro Yuasa, Angela Giangrande
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
Gcm
Online Access:https://elifesciences.org/articles/34890
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spelling doaj-4a14a0c8648c46d590c0e3d363c4c9d02021-05-05T16:00:46ZengeLife Sciences Publications LtdeLife2050-084X2018-07-01710.7554/eLife.34890Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in DrosophilaWael Bazzi0Pierre B Cattenoz1https://orcid.org/0000-0001-5301-1975Claude Delaporte2Vasanthi Dasari3Rosy Sakr4Yoshihiro Yuasa5Angela Giangrande6https://orcid.org/0000-0001-6278-5120Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; UMR7104, Centre National de la Recherche Scientifique, Illkirch, France; U1258, Institut National de la Santé et de la Recherche Médicale, Illkirch, France; Université de Strasbourg, Illkirch, FranceInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; UMR7104, Centre National de la Recherche Scientifique, Illkirch, France; U1258, Institut National de la Santé et de la Recherche Médicale, Illkirch, France; Université de Strasbourg, Illkirch, FranceInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; UMR7104, Centre National de la Recherche Scientifique, Illkirch, France; U1258, Institut National de la Santé et de la Recherche Médicale, Illkirch, France; Université de Strasbourg, Illkirch, FranceInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; UMR7104, Centre National de la Recherche Scientifique, Illkirch, France; U1258, Institut National de la Santé et de la Recherche Médicale, Illkirch, France; Université de Strasbourg, Illkirch, FranceInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; UMR7104, Centre National de la Recherche Scientifique, Illkirch, France; U1258, Institut National de la Santé et de la Recherche Médicale, Illkirch, France; Université de Strasbourg, Illkirch, FranceInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; UMR7104, Centre National de la Recherche Scientifique, Illkirch, France; U1258, Institut National de la Santé et de la Recherche Médicale, Illkirch, France; Université de Strasbourg, Illkirch, FranceInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; UMR7104, Centre National de la Recherche Scientifique, Illkirch, France; U1258, Institut National de la Santé et de la Recherche Médicale, Illkirch, France; Université de Strasbourg, Illkirch, FranceRecent lineage tracing analyses have significantly improved our understanding of immune system development and highlighted the importance of the different hematopoietic waves. The current challenge is to understand whether these waves interact and whether this affects the function of the immune system. Here we report a molecular pathway regulating the immune response and involving the communication between embryonic and larval hematopoietic waves in Drosophila. Down-regulating the transcription factor Gcm specific to embryonic hematopoiesis enhances the larval phenotypes induced by over-expressing the pro-inflammatory Jak/Stat pathway or by wasp infestation. Gcm works by modulating the transduction of the Upd cytokines to the site of larval hematopoiesis and hence the response to chronic (Jak/Stat over-expression) and acute (wasp infestation) immune challenges. Thus, homeostatic interactions control the function of the immune system in physiology and pathology. Our data also indicate that a transiently expressed developmental pathway has a long-lasting effect on the immune response.https://elifesciences.org/articles/34890DrosophilahematopoiesisJAK/STATinflammationtranscription factorsGcm
collection DOAJ
language English
format Article
sources DOAJ
author Wael Bazzi
Pierre B Cattenoz
Claude Delaporte
Vasanthi Dasari
Rosy Sakr
Yoshihiro Yuasa
Angela Giangrande
spellingShingle Wael Bazzi
Pierre B Cattenoz
Claude Delaporte
Vasanthi Dasari
Rosy Sakr
Yoshihiro Yuasa
Angela Giangrande
Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila
eLife
Drosophila
hematopoiesis
JAK/STAT
inflammation
transcription factors
Gcm
author_facet Wael Bazzi
Pierre B Cattenoz
Claude Delaporte
Vasanthi Dasari
Rosy Sakr
Yoshihiro Yuasa
Angela Giangrande
author_sort Wael Bazzi
title Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila
title_short Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila
title_full Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila
title_fullStr Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila
title_full_unstemmed Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila
title_sort embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in drosophila
publisher eLife Sciences Publications Ltd
series eLife
issn 2050-084X
publishDate 2018-07-01
description Recent lineage tracing analyses have significantly improved our understanding of immune system development and highlighted the importance of the different hematopoietic waves. The current challenge is to understand whether these waves interact and whether this affects the function of the immune system. Here we report a molecular pathway regulating the immune response and involving the communication between embryonic and larval hematopoietic waves in Drosophila. Down-regulating the transcription factor Gcm specific to embryonic hematopoiesis enhances the larval phenotypes induced by over-expressing the pro-inflammatory Jak/Stat pathway or by wasp infestation. Gcm works by modulating the transduction of the Upd cytokines to the site of larval hematopoiesis and hence the response to chronic (Jak/Stat over-expression) and acute (wasp infestation) immune challenges. Thus, homeostatic interactions control the function of the immune system in physiology and pathology. Our data also indicate that a transiently expressed developmental pathway has a long-lasting effect on the immune response.
topic Drosophila
hematopoiesis
JAK/STAT
inflammation
transcription factors
Gcm
url https://elifesciences.org/articles/34890
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