Assessment of VEGF, CD-31 and Ki-67 Immunohistochemical Markers in Oral Pyogenic Granuloma: A Comparison with Hemangioma and Inflammatory Gingivitis
AbstractObjective(s) The aim of this study was to evaluate the expressions of two angiogenic immune-markers (CD-31 and VEGF), and one proliferative immune-marker (Ki-67) in oral pyogenic granulomas (PG), hemangiomas (Hem) and inflammatory gingivitis (IG).Materials and MethodsSixty cases of PG, Hem a...
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Mashhad University of Medical Sciences
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doaj-4ad2aa40dade4651902569000a580a8b2020-11-24T23:32:22ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences 2008-38662008-38742011-03-011449Assessment of VEGF, CD-31 and Ki-67 Immunohistochemical Markers in Oral Pyogenic Granuloma: A Comparison with Hemangioma and Inflammatory GingivitisShadi SaghafiSakineh AmoueianMehdi MontazerRoshanak BostanAbstractObjective(s) The aim of this study was to evaluate the expressions of two angiogenic immune-markers (CD-31 and VEGF), and one proliferative immune-marker (Ki-67) in oral pyogenic granulomas (PG), hemangiomas (Hem) and inflammatory gingivitis (IG).Materials and MethodsSixty cases of PG, Hem and IG (twenty cases each) were examined. Immunohistochemical (IHC) staining was performed based on routine techniques. The microvessel density (MVD) index was also evaluated. ResultsThe male to female ratio was 1:2. The mean age was 33.3 years old (±20.52). The reactivity percentages for all three markers (CD-31, VEGF and Ki-67) were significantly higher in PG compared to Hem (56.8%, 13.8% and 23.0% vs. 28.3%, 7.0% and 5.4%, respectively). The mean MVD in PG was also significantly higher than in Hem (26.1±0.11 vs. 13.6±0.08). There was no statistically significant difference between PG and IG.ConclusionThe current study supports the common nature of pyogenic granulomas and inflammatory gingivitis. http://www.mums.ac.ir/shares/basic_medical/basicmedjou/2011/mar/a12.pdfCD31GingivitisHemangiomaKi-67 AntigenPyogenic GranulomaVEGF |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shadi Saghafi Sakineh Amoueian Mehdi Montazer Roshanak Bostan |
spellingShingle |
Shadi Saghafi Sakineh Amoueian Mehdi Montazer Roshanak Bostan Assessment of VEGF, CD-31 and Ki-67 Immunohistochemical Markers in Oral Pyogenic Granuloma: A Comparison with Hemangioma and Inflammatory Gingivitis Iranian Journal of Basic Medical Sciences CD31 Gingivitis Hemangioma Ki-67 Antigen Pyogenic Granuloma VEGF |
author_facet |
Shadi Saghafi Sakineh Amoueian Mehdi Montazer Roshanak Bostan |
author_sort |
Shadi Saghafi |
title |
Assessment of VEGF, CD-31 and Ki-67 Immunohistochemical Markers in Oral Pyogenic Granuloma: A Comparison with Hemangioma and Inflammatory Gingivitis |
title_short |
Assessment of VEGF, CD-31 and Ki-67 Immunohistochemical Markers in Oral Pyogenic Granuloma: A Comparison with Hemangioma and Inflammatory Gingivitis |
title_full |
Assessment of VEGF, CD-31 and Ki-67 Immunohistochemical Markers in Oral Pyogenic Granuloma: A Comparison with Hemangioma and Inflammatory Gingivitis |
title_fullStr |
Assessment of VEGF, CD-31 and Ki-67 Immunohistochemical Markers in Oral Pyogenic Granuloma: A Comparison with Hemangioma and Inflammatory Gingivitis |
title_full_unstemmed |
Assessment of VEGF, CD-31 and Ki-67 Immunohistochemical Markers in Oral Pyogenic Granuloma: A Comparison with Hemangioma and Inflammatory Gingivitis |
title_sort |
assessment of vegf, cd-31 and ki-67 immunohistochemical markers in oral pyogenic granuloma: a comparison with hemangioma and inflammatory gingivitis |
publisher |
Mashhad University of Medical Sciences |
series |
Iranian Journal of Basic Medical Sciences |
issn |
2008-3866 2008-3874 |
publishDate |
2011-03-01 |
description |
AbstractObjective(s) The aim of this study was to evaluate the expressions of two angiogenic immune-markers (CD-31 and VEGF), and one proliferative immune-marker (Ki-67) in oral pyogenic granulomas (PG), hemangiomas (Hem) and inflammatory gingivitis (IG).Materials and MethodsSixty cases of PG, Hem and IG (twenty cases each) were examined. Immunohistochemical (IHC) staining was performed based on routine techniques. The microvessel density (MVD) index was also evaluated. ResultsThe male to female ratio was 1:2. The mean age was 33.3 years old (±20.52). The reactivity percentages for all three markers (CD-31, VEGF and Ki-67) were significantly higher in PG compared to Hem (56.8%, 13.8% and 23.0% vs. 28.3%, 7.0% and 5.4%, respectively). The mean MVD in PG was also significantly higher than in Hem (26.1±0.11 vs. 13.6±0.08). There was no statistically significant difference between PG and IG.ConclusionThe current study supports the common nature of pyogenic granulomas and inflammatory gingivitis. |
topic |
CD31 Gingivitis Hemangioma Ki-67 Antigen Pyogenic Granuloma VEGF |
url |
http://www.mums.ac.ir/shares/basic_medical/basicmedjou/2011/mar/a12.pdf |
work_keys_str_mv |
AT shadisaghafi assessmentofvegfcd31andki67immunohistochemicalmarkersinoralpyogenicgranulomaacomparisonwithhemangiomaandinflammatorygingivitis AT sakinehamoueian assessmentofvegfcd31andki67immunohistochemicalmarkersinoralpyogenicgranulomaacomparisonwithhemangiomaandinflammatorygingivitis AT mehdimontazer assessmentofvegfcd31andki67immunohistochemicalmarkersinoralpyogenicgranulomaacomparisonwithhemangiomaandinflammatorygingivitis AT roshanakbostan assessmentofvegfcd31andki67immunohistochemicalmarkersinoralpyogenicgranulomaacomparisonwithhemangiomaandinflammatorygingivitis |
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