Drug Utilization Study of Antibiotics in Bacterial Meningitis (A Retrospective Study in Dr. Soetomo General Hospital, Surabaya, Indonesia)

Background: Meningitis defined as an inflammation of the meninges, a membrane that surrounds the brain. The inflammation is a result from bacterial infection. Central nervous system infection is a medical emergency because of the progressivity and potentially life-threatening. Antibiotics usage beco...

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Main Authors: Mareta Rindang Andarsari, Didik Hasmono, Samirah Samirah, Suharjono Suharjono, Dea Ayu Nabilah, Paulus Sugianto
Format: Article
Language:Indonesian
Published: Faculty of Pharmacy, Universitas Airlangga 2019-02-01
Series:Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Subjects:
Online Access:https://e-journal.unair.ac.id/JFIKI/article/view/9141
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spelling doaj-4afb21f4086240a39dfa9673f39522d82021-01-05T07:55:57ZindFaculty of Pharmacy, Universitas AirlanggaJurnal Farmasi dan Ilmu Kefarmasian Indonesia2406-93882580-83032019-02-0142808310.20473/jfiki.v4i22017.80-835165Drug Utilization Study of Antibiotics in Bacterial Meningitis (A Retrospective Study in Dr. Soetomo General Hospital, Surabaya, Indonesia)Mareta Rindang Andarsari0Didik Hasmono1Samirah Samirah2Suharjono Suharjono3Dea Ayu Nabilah4Paulus Sugianto5Universitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaRSUD Dr. SoetomoBackground: Meningitis defined as an inflammation of the meninges, a membrane that surrounds the brain. The inflammation is a result from bacterial infection. Central nervous system infection is a medical emergency because of the progressivity and potentially life-threatening. Antibiotics usage become crucial to reduce morbidity and mortality. Objective: This study was aimed to assess the use of antibiotics, prescribed for patients with bacterial meningitis in Neurology Department of Dr. Soetomo General Hospital Surabaya from January 2010 until June 2015. Methods: Retrospective study using medical record of inpatients obtained from January 1st 2010 until June 30th 2015. The inclusion criteria were inpatients with bacterial meningitis (diagnosed by physician using CT scan data, lumbal puncture and clinical signs and symptoms) and prescribed with antibiotics. Patients with antibiotics therapy less than 3 days and infection other than bacterials were excluded. Results: From 85 patients, male to female ratio was 1.66. Meningitis appear to be mostly occured in productive age, 39 (45.88%) in 15 - 29 years old and 40 (47.06%) in 30 - 60 years old. Number of antibiotics prescribed were 130 prescriptions, as single and combination therapy. The most prescribed antibiotic was cephalosporins (97 prescriptions), dominated by 2 g twice daily ceftriaxone with 86 (66.15%) from overall prescriptions. Followed by metronidazole and fluoroquinolons,11 (8.46%) and 8 (6.15%) respectively. In addition, there were 26 prescriptions of combination therapy, mostly ceftriaxone and metronidazole. Conclusion: Bacterial meningitis are mostly treated using ceftriaxone which is an appropriate drug of choice.https://e-journal.unair.ac.id/JFIKI/article/view/9141antibiotics, bacterial meningitis, drug utilization study, ceftriaxone
collection DOAJ
language Indonesian
format Article
sources DOAJ
author Mareta Rindang Andarsari
Didik Hasmono
Samirah Samirah
Suharjono Suharjono
Dea Ayu Nabilah
Paulus Sugianto
spellingShingle Mareta Rindang Andarsari
Didik Hasmono
Samirah Samirah
Suharjono Suharjono
Dea Ayu Nabilah
Paulus Sugianto
Drug Utilization Study of Antibiotics in Bacterial Meningitis (A Retrospective Study in Dr. Soetomo General Hospital, Surabaya, Indonesia)
Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
antibiotics, bacterial meningitis, drug utilization study, ceftriaxone
author_facet Mareta Rindang Andarsari
Didik Hasmono
Samirah Samirah
Suharjono Suharjono
Dea Ayu Nabilah
Paulus Sugianto
author_sort Mareta Rindang Andarsari
title Drug Utilization Study of Antibiotics in Bacterial Meningitis (A Retrospective Study in Dr. Soetomo General Hospital, Surabaya, Indonesia)
title_short Drug Utilization Study of Antibiotics in Bacterial Meningitis (A Retrospective Study in Dr. Soetomo General Hospital, Surabaya, Indonesia)
title_full Drug Utilization Study of Antibiotics in Bacterial Meningitis (A Retrospective Study in Dr. Soetomo General Hospital, Surabaya, Indonesia)
title_fullStr Drug Utilization Study of Antibiotics in Bacterial Meningitis (A Retrospective Study in Dr. Soetomo General Hospital, Surabaya, Indonesia)
title_full_unstemmed Drug Utilization Study of Antibiotics in Bacterial Meningitis (A Retrospective Study in Dr. Soetomo General Hospital, Surabaya, Indonesia)
title_sort drug utilization study of antibiotics in bacterial meningitis (a retrospective study in dr. soetomo general hospital, surabaya, indonesia)
publisher Faculty of Pharmacy, Universitas Airlangga
series Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
issn 2406-9388
2580-8303
publishDate 2019-02-01
description Background: Meningitis defined as an inflammation of the meninges, a membrane that surrounds the brain. The inflammation is a result from bacterial infection. Central nervous system infection is a medical emergency because of the progressivity and potentially life-threatening. Antibiotics usage become crucial to reduce morbidity and mortality. Objective: This study was aimed to assess the use of antibiotics, prescribed for patients with bacterial meningitis in Neurology Department of Dr. Soetomo General Hospital Surabaya from January 2010 until June 2015. Methods: Retrospective study using medical record of inpatients obtained from January 1st 2010 until June 30th 2015. The inclusion criteria were inpatients with bacterial meningitis (diagnosed by physician using CT scan data, lumbal puncture and clinical signs and symptoms) and prescribed with antibiotics. Patients with antibiotics therapy less than 3 days and infection other than bacterials were excluded. Results: From 85 patients, male to female ratio was 1.66. Meningitis appear to be mostly occured in productive age, 39 (45.88%) in 15 - 29 years old and 40 (47.06%) in 30 - 60 years old. Number of antibiotics prescribed were 130 prescriptions, as single and combination therapy. The most prescribed antibiotic was cephalosporins (97 prescriptions), dominated by 2 g twice daily ceftriaxone with 86 (66.15%) from overall prescriptions. Followed by metronidazole and fluoroquinolons,11 (8.46%) and 8 (6.15%) respectively. In addition, there were 26 prescriptions of combination therapy, mostly ceftriaxone and metronidazole. Conclusion: Bacterial meningitis are mostly treated using ceftriaxone which is an appropriate drug of choice.
topic antibiotics, bacterial meningitis, drug utilization study, ceftriaxone
url https://e-journal.unair.ac.id/JFIKI/article/view/9141
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