Mesenchymal stem cell‐derived extracellular vesicles for the treatment of acute respiratory distress syndrome
Abstract Acute respiratory distress syndrome (ARDS) is a serious and potentially fatal acute inflammatory lung condition which currently has no specific treatments targeting its pathophysiology. However, mesenchymal stem cells have been shown to have very promising therapeutic potential, and recentl...
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Online Access: | https://doi.org/10.1002/sctm.19-0205 |
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doaj-4b352195e32940fe8bfac5c8e94861192020-11-25T01:42:28ZengWileyStem Cells Translational Medicine2157-65642157-65802020-01-0191283810.1002/sctm.19-0205Mesenchymal stem cell‐derived extracellular vesicles for the treatment of acute respiratory distress syndromeAswin Abraham0Anna Krasnodembskaya1Wellcome‐Wolfson Institute for Experimental Medicine Queen's University of Belfast Belfast United KingdomWellcome‐Wolfson Institute for Experimental Medicine Queen's University of Belfast Belfast United KingdomAbstract Acute respiratory distress syndrome (ARDS) is a serious and potentially fatal acute inflammatory lung condition which currently has no specific treatments targeting its pathophysiology. However, mesenchymal stem cells have been shown to have very promising therapeutic potential, and recently, it has been established that their effect is largely due to the transfer of extracellular vesicles (EVs). EVs have been shown to transfer a variety of substances such as mRNA, miRNA, and even organelles such as mitochondria in order to ameliorate ARDS in preclinical models. In addition, the fact that they have been proven to have the same effect as their parent cells combined with their numerous advantages over whole cell administration means that they are a promising candidate for clinical application that merits further research.https://doi.org/10.1002/sctm.19-0205cellular therapyclinical translationmesenchymal stem cells (MSCs)respiratory tract |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aswin Abraham Anna Krasnodembskaya |
spellingShingle |
Aswin Abraham Anna Krasnodembskaya Mesenchymal stem cell‐derived extracellular vesicles for the treatment of acute respiratory distress syndrome Stem Cells Translational Medicine cellular therapy clinical translation mesenchymal stem cells (MSCs) respiratory tract |
author_facet |
Aswin Abraham Anna Krasnodembskaya |
author_sort |
Aswin Abraham |
title |
Mesenchymal stem cell‐derived extracellular vesicles for the treatment of acute respiratory distress syndrome |
title_short |
Mesenchymal stem cell‐derived extracellular vesicles for the treatment of acute respiratory distress syndrome |
title_full |
Mesenchymal stem cell‐derived extracellular vesicles for the treatment of acute respiratory distress syndrome |
title_fullStr |
Mesenchymal stem cell‐derived extracellular vesicles for the treatment of acute respiratory distress syndrome |
title_full_unstemmed |
Mesenchymal stem cell‐derived extracellular vesicles for the treatment of acute respiratory distress syndrome |
title_sort |
mesenchymal stem cell‐derived extracellular vesicles for the treatment of acute respiratory distress syndrome |
publisher |
Wiley |
series |
Stem Cells Translational Medicine |
issn |
2157-6564 2157-6580 |
publishDate |
2020-01-01 |
description |
Abstract Acute respiratory distress syndrome (ARDS) is a serious and potentially fatal acute inflammatory lung condition which currently has no specific treatments targeting its pathophysiology. However, mesenchymal stem cells have been shown to have very promising therapeutic potential, and recently, it has been established that their effect is largely due to the transfer of extracellular vesicles (EVs). EVs have been shown to transfer a variety of substances such as mRNA, miRNA, and even organelles such as mitochondria in order to ameliorate ARDS in preclinical models. In addition, the fact that they have been proven to have the same effect as their parent cells combined with their numerous advantages over whole cell administration means that they are a promising candidate for clinical application that merits further research. |
topic |
cellular therapy clinical translation mesenchymal stem cells (MSCs) respiratory tract |
url |
https://doi.org/10.1002/sctm.19-0205 |
work_keys_str_mv |
AT aswinabraham mesenchymalstemcellderivedextracellularvesiclesforthetreatmentofacuterespiratorydistresssyndrome AT annakrasnodembskaya mesenchymalstemcellderivedextracellularvesiclesforthetreatmentofacuterespiratorydistresssyndrome |
_version_ |
1725036088250073088 |