Noise-driven causal inference in biomolecular networks.

Single-cell RNA and protein concentrations dynamically fluctuate because of stochastic ("noisy") regulation. Consequently, biological signaling and genetic networks not only translate stimuli with functional response but also random fluctuations. Intuitively, this feature manifests as the...

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Bibliographic Details
Main Authors: Robert J Prill, Robert Vogel, Guillermo A Cecchi, Grégoire Altan-Bonnet, Gustavo Stolovitzky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4452541?pdf=render