Smad3 Deficiency Ameliorates Hepatic Fibrogenesis through the Expression of Senescence Marker Protein-30, an Antioxidant-Related Protein

Smad3 Deficiency Ameliorates Hepatic Fibrogenesis through the Expression of Senescence Marker Protein-30, an Antioxidant-Related Protein

Smad3 is a key mediator of the transforming growth factor (TGF)-β1 signaling pathway that plays central role in inflammation and fibrosis. In present study, we evaluated the effect of Smad3 deficiency in Smad3−/− mice with carbon tetrachloride (CCl4)-induced liver fibrosis. The animals were received...

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Bibliographic Details
Main Authors: Da-Hee Jeong, Meeyul Hwang, Jin-Kyu Park, Moon-Jung Goo, Il-Hwa Hong, Mi-Ran Ki, Akihito Ishigami, Ah-Young Kim, Eun-Mi Lee, Eun-Joo Lee, Kyu-Shik Jeong
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:International Journal of Molecular Sciences
Subjects:
liver fibrosis
Smad3
SMP-30
antioxidant
Online Access:http://www.mdpi.com/1422-0067/14/12/23700

Internet

http://www.mdpi.com/1422-0067/14/12/23700

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