Enhanced O-linked Glcnacylation in Crohn's disease promotes intestinal inflammation

Enhanced O-linked Glcnacylation in Crohn's disease promotes intestinal inflammation

Background: Treatment of Crohn's disease (CD) remains to be a challenge due to limited insights for its pathogenesis. We aimed to determine the role of O-Linked β-N-acetylglucosamine (O-GlcNAc) in the development of CD and evaluate therapeutic effects of O-GlcNAc inhibitors on CD. Methods: O-Gl...

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Bibliographic Details
Main Authors: Qian-Hui Sun, Yi-Shu Wang, Guolong Liu, Hong-Lan Zhou, Yong-Ping Jian, Ming-Di Liu, Dan Zhang, Qiang Ding, Rui-Xun Zhao, Jian-Feng Chen, Yi-Ning Li, Jiyong Liang, Yu-Lin Li, Cheng-Shi Quan, Zhi-Xiang Xu
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420300682

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http://www.sciencedirect.com/science/article/pii/S2352396420300682

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