QUANTITATIVE PARAMETERS OF NUCLEAR AND FREE CELL DNA IN NEWBORN BABIES WITH CLINICAL MANIFESTATIONS OF ADAPTATION DERANGEMENT IN EARLY NEONATAL PERIOD

QUANTITATIVE PARAMETERS OF NUCLEAR AND FREE CELL DNA IN NEWBORN BABIES WITH CLINICAL MANIFESTATIONS OF ADAPTATION DERANGEMENT IN EARLY NEONATAL PERIOD

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<em>In the paper were presented the results of an investigation of the nucleus area and metabolism DNA parameters (the level of nuclear DNA uptake, the level of a chromatin condensation and the concentration of plasma free cell DNA) in newborns with clinical manifestations of adaptation derang...

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Main Authors: V.V. Sofronov, N.O. Tuaeva, V.G. Vinter, V.A. Emikeeva, D.I. Shegurova, E.V. Mavrina
Format: Article
Language:English
Published: "Paediatrician" Publishers LLC 2006-01-01
Series:Voprosy Sovremennoj Pediatrii
Online Access:http://vsp.spr-journal.ru:80/jour/article/view/1526
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spelling doaj-4bd75d308a6b43f68e03bce6578529b82020-11-24T22:56:16Zeng"Paediatrician" Publishers LLC Voprosy Sovremennoj Pediatrii1682-55271682-55352006-01-015628311521QUANTITATIVE PARAMETERS OF NUCLEAR AND FREE CELL DNA IN NEWBORN BABIES WITH CLINICAL MANIFESTATIONS OF ADAPTATION DERANGEMENT IN EARLY NEONATAL PERIODV.V. Sofronov0N.O. Tuaeva1V.G. Vinter2V.A. Emikeeva3D.I. Shegurova4E.V. Mavrina5Kazan State Medical UniversityKazan State UniversityKazan State UniversityKazan State Medical UniversityKazan State Medical UniversityChildren's City Clinical Hospital № 1, Kazan<em>In the paper were presented the results of an investigation of the nucleus area and metabolism DNA parameters (the level of nuclear DNA uptake, the level of a chromatin condensation and the concentration of plasma free cell DNA) in newborns with clinical manifestations of adaptation derangement (a perinatal CNS damage, an intrauterine pneumonia and a neonatal pneumopathy) in early neonatal period. In all cases the disorders of a DNA metabolism was obtained. However, the greatest divergence of all investigated parameters was founded in newborns with neonatal pneumo pathy. We made the assumption that lymphocyte apoptosis may be part of the reason for the origin of free cell DNA and we propose the possible mechanism of free cell DNA sharing in pathogenesis of derangement adaptation in neonatal period.</em><br /><strong><em>Key words: free cell DNA, nuclear DNA, intrauterine pneumonia, pneumopathy.</em></strong>http://vsp.spr-journal.ru:80/jour/article/view/1526
collection DOAJ
language English
format Article
sources DOAJ
author V.V. Sofronov
N.O. Tuaeva
V.G. Vinter
V.A. Emikeeva
D.I. Shegurova
E.V. Mavrina
spellingShingle V.V. Sofronov
N.O. Tuaeva
V.G. Vinter
V.A. Emikeeva
D.I. Shegurova
E.V. Mavrina
QUANTITATIVE PARAMETERS OF NUCLEAR AND FREE CELL DNA IN NEWBORN BABIES WITH CLINICAL MANIFESTATIONS OF ADAPTATION DERANGEMENT IN EARLY NEONATAL PERIOD
Voprosy Sovremennoj Pediatrii
author_facet V.V. Sofronov
N.O. Tuaeva
V.G. Vinter
V.A. Emikeeva
D.I. Shegurova
E.V. Mavrina
author_sort V.V. Sofronov
title QUANTITATIVE PARAMETERS OF NUCLEAR AND FREE CELL DNA IN NEWBORN BABIES WITH CLINICAL MANIFESTATIONS OF ADAPTATION DERANGEMENT IN EARLY NEONATAL PERIOD
title_short QUANTITATIVE PARAMETERS OF NUCLEAR AND FREE CELL DNA IN NEWBORN BABIES WITH CLINICAL MANIFESTATIONS OF ADAPTATION DERANGEMENT IN EARLY NEONATAL PERIOD
title_full QUANTITATIVE PARAMETERS OF NUCLEAR AND FREE CELL DNA IN NEWBORN BABIES WITH CLINICAL MANIFESTATIONS OF ADAPTATION DERANGEMENT IN EARLY NEONATAL PERIOD
title_fullStr QUANTITATIVE PARAMETERS OF NUCLEAR AND FREE CELL DNA IN NEWBORN BABIES WITH CLINICAL MANIFESTATIONS OF ADAPTATION DERANGEMENT IN EARLY NEONATAL PERIOD
title_full_unstemmed QUANTITATIVE PARAMETERS OF NUCLEAR AND FREE CELL DNA IN NEWBORN BABIES WITH CLINICAL MANIFESTATIONS OF ADAPTATION DERANGEMENT IN EARLY NEONATAL PERIOD
title_sort quantitative parameters of nuclear and free cell dna in newborn babies with clinical manifestations of adaptation derangement in early neonatal period
publisher "Paediatrician" Publishers LLC
series Voprosy Sovremennoj Pediatrii
issn 1682-5527
1682-5535
publishDate 2006-01-01
description <em>In the paper were presented the results of an investigation of the nucleus area and metabolism DNA parameters (the level of nuclear DNA uptake, the level of a chromatin condensation and the concentration of plasma free cell DNA) in newborns with clinical manifestations of adaptation derangement (a perinatal CNS damage, an intrauterine pneumonia and a neonatal pneumopathy) in early neonatal period. In all cases the disorders of a DNA metabolism was obtained. However, the greatest divergence of all investigated parameters was founded in newborns with neonatal pneumo pathy. We made the assumption that lymphocyte apoptosis may be part of the reason for the origin of free cell DNA and we propose the possible mechanism of free cell DNA sharing in pathogenesis of derangement adaptation in neonatal period.</em><br /><strong><em>Key words: free cell DNA, nuclear DNA, intrauterine pneumonia, pneumopathy.</em></strong>
url http://vsp.spr-journal.ru:80/jour/article/view/1526
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