Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

Abstract Insoluble intracellular aggregation of tau proteins into filaments and neurodegeneration are histopathological hallmarks of Alzheimer disease (AD) and other tauopathies. Recently, prefibrillar, soluble, oligomeric tau intermediates have emerged as relevant pathological tau species; however,...

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Bibliographic Details
Main Authors: Jin Zheng, Mansour Akbari, Claire Schirmer, Marie-Line Reynaert, Anne Loyens, Bruno Lefebvre, Luc Buée, Deborah L. Croteau, Marie-Christine Galas, Vilhelm A. Bohr
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Acta Neuropathologica Communications
Subjects:
Tau oligomerization
Mitochondrial homeostasis
Polymerase beta
Oxidative stress
Tauopathies
Online Access:http://link.springer.com/article/10.1186/s40478-020-00896-8

Internet

http://link.springer.com/article/10.1186/s40478-020-00896-8

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