Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target.

Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target.

BACKGROUND:Plasmodium falciparum parasitization of erythrocytes causes a substantial increase in the levels of intracellular fatty acids, notably oleic acid. How parasites acquire this monounsaturated fatty acid has remained enigmatic. Here, we report on the biochemical and enzymatic characterizatio...

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Bibliographic Details
Main Authors: Paul Gratraud, Enlli Huws, Brie Falkard, Sophie Adjalley, David A Fidock, Laurence Berry, William R Jacobs, Mark S Baird, Henri Vial, Laurent Kremer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2731242?pdf=render

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http://europepmc.org/articles/PMC2731242?pdf=render

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