Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration

Purpose: To evaluate the effect of two intravitreal bevacizumab (IVB) injections on peripapillary retinal nerve fiber layer (RNFL) thickness in patients with wet type age-related macular degeneration (ARMD). Methods: This prospective interventional case series included 18 eyes of 18 patients receiv...

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Main Authors: Morteza Entezari, Alireza Ramezani, Mehdi Yaseri
Format: Article
Language:English
Published: Knowledge E 2014-01-01
Series:Journal of Ophthalmic & Vision Research
Subjects:
Online Access:http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=4;spage=449;epage=452;aulast=Entezari
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spelling doaj-4cb06301799d4202af5c8aa154f48f3d2020-11-25T01:34:25ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2014-01-019444945210.4103/2008-322X.150815Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degenerationMorteza EntezariAlireza RamezaniMehdi YaseriPurpose: To evaluate the effect of two intravitreal bevacizumab (IVB) injections on peripapillary retinal nerve fiber layer (RNFL) thickness in patients with wet type age-related macular degeneration (ARMD). Methods: This prospective interventional case series included 18 eyes of 18 patients receiving two IVB injections within a 6 weeks interval for treatment of wet type ARMD. Peripapillary RNFL thickness was measured prior to the first injection, and 12 and 24 weeks afterwards by optical coherence tomography (3D OCT-1000, Topcon Corporation, Tokyo, Japan). Mean RNFL thickness and values in the four peripapillary quadrants were compared at baseline, and 12 and 24 weeks after initial injection. Results: Mean RNFL thickness was 89 ± 21 μm at baseline which was significantly reduced to 82 ± 15 μm at 12 weeks (P = 0.021). At final follow-up (week 24), mean RNFL thickness reached 87 ± 23 μm and was comparable to baseline values (P = 0.356). Only the temporal quadrant showed a significant reduction in RNFL thickness at 12 weeks (P = 0.033); this quadrant followed the same pattern of change as the mean RNFL thickness, becoming comparable to pre-injection values at 24 weeks (P = 0. 298). Conclusion: RNFL thickness may decrease temporarily following two IVB injections in patients with wet type ARMD; however, in the long-term no significant change was detectable from baseline values.http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=4;spage=449;epage=452;aulast=EntezariAge-related Macular Degeneration; Bevacizumab; Optical Coherence Tomography; Retinal Nerve Fiber Layer
collection DOAJ
language English
format Article
sources DOAJ
author Morteza Entezari
Alireza Ramezani
Mehdi Yaseri
spellingShingle Morteza Entezari
Alireza Ramezani
Mehdi Yaseri
Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration
Journal of Ophthalmic & Vision Research
Age-related Macular Degeneration; Bevacizumab; Optical Coherence Tomography; Retinal Nerve Fiber Layer
author_facet Morteza Entezari
Alireza Ramezani
Mehdi Yaseri
author_sort Morteza Entezari
title Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration
title_short Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration
title_full Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration
title_fullStr Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration
title_full_unstemmed Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration
title_sort changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration
publisher Knowledge E
series Journal of Ophthalmic & Vision Research
issn 2008-322X
publishDate 2014-01-01
description Purpose: To evaluate the effect of two intravitreal bevacizumab (IVB) injections on peripapillary retinal nerve fiber layer (RNFL) thickness in patients with wet type age-related macular degeneration (ARMD). Methods: This prospective interventional case series included 18 eyes of 18 patients receiving two IVB injections within a 6 weeks interval for treatment of wet type ARMD. Peripapillary RNFL thickness was measured prior to the first injection, and 12 and 24 weeks afterwards by optical coherence tomography (3D OCT-1000, Topcon Corporation, Tokyo, Japan). Mean RNFL thickness and values in the four peripapillary quadrants were compared at baseline, and 12 and 24 weeks after initial injection. Results: Mean RNFL thickness was 89 ± 21 μm at baseline which was significantly reduced to 82 ± 15 μm at 12 weeks (P = 0.021). At final follow-up (week 24), mean RNFL thickness reached 87 ± 23 μm and was comparable to baseline values (P = 0.356). Only the temporal quadrant showed a significant reduction in RNFL thickness at 12 weeks (P = 0.033); this quadrant followed the same pattern of change as the mean RNFL thickness, becoming comparable to pre-injection values at 24 weeks (P = 0. 298). Conclusion: RNFL thickness may decrease temporarily following two IVB injections in patients with wet type ARMD; however, in the long-term no significant change was detectable from baseline values.
topic Age-related Macular Degeneration; Bevacizumab; Optical Coherence Tomography; Retinal Nerve Fiber Layer
url http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=4;spage=449;epage=452;aulast=Entezari
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AT mehdiyaseri changesinretinalnervefiberlayerthicknessaftertwointravitrealbevacizumabinjectionsforwettypeagerelatedmaculardegeneration
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