Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration
Purpose: To evaluate the effect of two intravitreal bevacizumab (IVB) injections on peripapillary retinal nerve fiber layer (RNFL) thickness in patients with wet type age-related macular degeneration (ARMD). Methods: This prospective interventional case series included 18 eyes of 18 patients receiv...
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doaj-4cb06301799d4202af5c8aa154f48f3d2020-11-25T01:34:25ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2014-01-019444945210.4103/2008-322X.150815Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degenerationMorteza EntezariAlireza RamezaniMehdi YaseriPurpose: To evaluate the effect of two intravitreal bevacizumab (IVB) injections on peripapillary retinal nerve fiber layer (RNFL) thickness in patients with wet type age-related macular degeneration (ARMD). Methods: This prospective interventional case series included 18 eyes of 18 patients receiving two IVB injections within a 6 weeks interval for treatment of wet type ARMD. Peripapillary RNFL thickness was measured prior to the first injection, and 12 and 24 weeks afterwards by optical coherence tomography (3D OCT-1000, Topcon Corporation, Tokyo, Japan). Mean RNFL thickness and values in the four peripapillary quadrants were compared at baseline, and 12 and 24 weeks after initial injection. Results: Mean RNFL thickness was 89 ± 21 μm at baseline which was significantly reduced to 82 ± 15 μm at 12 weeks (P = 0.021). At final follow-up (week 24), mean RNFL thickness reached 87 ± 23 μm and was comparable to baseline values (P = 0.356). Only the temporal quadrant showed a significant reduction in RNFL thickness at 12 weeks (P = 0.033); this quadrant followed the same pattern of change as the mean RNFL thickness, becoming comparable to pre-injection values at 24 weeks (P = 0. 298). Conclusion: RNFL thickness may decrease temporarily following two IVB injections in patients with wet type ARMD; however, in the long-term no significant change was detectable from baseline values.http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=4;spage=449;epage=452;aulast=EntezariAge-related Macular Degeneration; Bevacizumab; Optical Coherence Tomography; Retinal Nerve Fiber Layer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Morteza Entezari Alireza Ramezani Mehdi Yaseri |
spellingShingle |
Morteza Entezari Alireza Ramezani Mehdi Yaseri Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration Journal of Ophthalmic & Vision Research Age-related Macular Degeneration; Bevacizumab; Optical Coherence Tomography; Retinal Nerve Fiber Layer |
author_facet |
Morteza Entezari Alireza Ramezani Mehdi Yaseri |
author_sort |
Morteza Entezari |
title |
Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration |
title_short |
Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration |
title_full |
Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration |
title_fullStr |
Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration |
title_full_unstemmed |
Changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration |
title_sort |
changes in retinal nerve fiber layer thickness after two intravitreal bevacizumab injections for wet type age-related macular degeneration |
publisher |
Knowledge E |
series |
Journal of Ophthalmic & Vision Research |
issn |
2008-322X |
publishDate |
2014-01-01 |
description |
Purpose: To evaluate the effect of two intravitreal bevacizumab (IVB) injections on peripapillary retinal nerve fiber layer (RNFL) thickness in patients with wet type age-related macular degeneration (ARMD).
Methods: This prospective interventional case series included 18 eyes of 18 patients receiving two IVB injections within a 6 weeks interval for treatment of wet type ARMD. Peripapillary RNFL thickness was measured prior to the first injection, and 12 and 24 weeks afterwards by optical coherence tomography (3D OCT-1000, Topcon Corporation, Tokyo, Japan). Mean RNFL thickness and values in the four peripapillary quadrants were compared at baseline, and 12 and 24 weeks after initial injection.
Results: Mean RNFL thickness was 89 ± 21 μm at baseline which was significantly reduced to 82 ± 15 μm at 12 weeks (P = 0.021). At final follow-up (week 24), mean RNFL thickness reached 87 ± 23 μm and was comparable to baseline values (P = 0.356). Only the temporal quadrant showed a significant reduction in RNFL thickness at 12 weeks (P = 0.033); this quadrant followed the same pattern of change as the mean RNFL thickness, becoming comparable to pre-injection values at 24 weeks (P = 0. 298).
Conclusion: RNFL thickness may decrease temporarily following two IVB injections in patients with wet type ARMD; however, in the long-term no significant change was detectable from baseline values. |
topic |
Age-related Macular Degeneration; Bevacizumab; Optical Coherence Tomography; Retinal Nerve Fiber Layer |
url |
http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=4;spage=449;epage=452;aulast=Entezari |
work_keys_str_mv |
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