Interleukin-1 Receptor Antagonist Protects Newborn Mice Against Pulmonary Hypertension

Interleukin-1 Receptor Antagonist Protects Newborn Mice Against Pulmonary Hypertension

Pulmonary hypertension secondary to bronchopulmonary dysplasia (BPD-PH) represents a major complication of BPD in extremely preterm infants for which there are currently no safe and effective interventions. The abundance of interleukin-1 (IL-1) is strongly correlated with the severity and long-term...

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Bibliographic Details
Main Authors: Christine B. Bui, Magdalena Kolodziej, Emma Lamanna, Kirstin Elgass, Arvind Sehgal, Ina Rudloff, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Maurice A. G. M. Kroon, Steven X. Cho, Anton Maksimenko, Marian Cholewa, Philip J. Berger, Morag J. Young, Jane E. Bourke, James T. Pearson, Marcel F. Nold, Claudia A. Nold-Petry
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
pulmonary hypertension
bronchopulmonary dysplasia
interleukin-1 receptor antagonist
pulmonary vascular resistance
neonatal immunity
anti-inflammatory therapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01480/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01480/full

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