Sugar analog synthesis by in vitro biocatalytic cascade: A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis.

Sugar analog synthesis by in vitro biocatalytic cascade: A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis.

Carbon-carbon bond formation is one of the most challenging reactions in synthetic organic chemistry, and aldol reactions catalysed by dihydroxyacetone phosphate-dependent aldolases provide a powerful biocatalytic tool for combining C-C bond formation with the generation of two new stereo-centres, w...

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Bibliographic Details
Main Authors: Carol J Hartley, Nigel G French, Judith A Scoble, Charlotte C Williams, Quentin I Churches, Andrew R Frazer, Matthew C Taylor, Greg Coia, Gregory Simpson, Nicholas J Turner, Colin Scott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5675407?pdf=render

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http://europepmc.org/articles/PMC5675407?pdf=render

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