Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke

Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke

Abstract Background Cooling may reduce infarct size and improve neurological outcomes in patients with ischaemic stroke. In phase II trials, cooling awake patients with ischaemic stroke has been shown to be feasible and safe, but the effects in functional outcomes has not yet been investigated in an...

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Bibliographic Details
Main Authors: Per Winkel, Philip M. Bath, Christian Gluud, Jane Lindschou, H. Bart van der Worp, Malcolm R. Macleod, Istvan Szabo, Isabelle Durand-Zaleski, Stefan Schwab, for the EuroHYP-1 trial investigators
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Trials
Subjects:
Acute ischaemic stroke
Randomised clinical trial
Modified Ranking scale
Quality of life
Cooling
Cost-effectiveness
Online Access:http://link.springer.com/article/10.1186/s13063-017-2302-z

Internet

http://link.springer.com/article/10.1186/s13063-017-2302-z

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