Neuroprotective effect of quercetin in a model of Parkinson’s disease in rat: A histochemical analysis

• Main Authors: Mehdi Mehdizadeh, Mohammad Taghi Joghataei, Maliheh Nobakht, Roya Aryanpour
• Format: Article
• Language: English
• Published: Iran University of Medical Sciences 2009-01-01
• Series: Basic and Clinical Neuroscience
• Subjects: Quercetin; 6-Hydroxydopamine; Parkinson’s disease; Rat
• Online Access: http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-1&slc_lang=en&sid=1

AbstractIntroduction: Parkinson's disease (PD) is a neuropathological disorder involving the degeneration of dopaminergic neurons in the substantia nigra, with the subsequent loss of their terminals in the striatum. Quercetin, a natural flavonoid, is a strong antioxidant and radical scavenger. Therefore, its neuroprotective effect in a model of Parkinson’s disease in rat was evaluated.Methods: For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated with quercetin (20 mg/kg i.p.) 1 hour before surgery and treated once a day for one month. Nissl-stained neurons of substantia nigra pars compacta (SNC) were counted. Results: Number of Nissl-stained neurons in left side of SNC of lesion group was lower relative to sham-operated group (p<0.005) and it was higher in quercetin-treated lesion group as compared to untreated lesion group (p<0.01).Discussion: Flavonoid quercetin administration for one month could protect the neurons of SNC against 6-OHDA toxicity.