Metabolic Stability Assessment of New PARP Inhibitor Talazoparib Using Validated LC–MS/MS Methodology: In silico Metabolic Vulnerability and Toxicity Studies

Metabolic Stability Assessment of New PARP Inhibitor Talazoparib Using Validated LC–MS/MS Methodology: In silico Metabolic Vulnerability and Toxicity Studies

Mohamed W Attwa, 1, 2 Adnan A Kadi, 1 Ali S Abdelhameed, 1 Hassan A Alhazmi 3, 4 1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; 2Students’ University Hospital, Mansoura University, Mansoura 35516, Egypt; 3Department of Pha...

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Bibliographic Details
Main Authors: Attwa MW, Kadi AA, Abdelhameed AS, Alhazmi HA
Format: Article
Language:English
Published: Dove Medical Press 2020-02-01
Series:Drug Design, Development and Therapy
Subjects:
talazoparib
metabolic stability evaluation
human liver microsomes
tandem mass spectrometry
derek
stardrop software.
Online Access:https://www.dovepress.com/metabolic-stability-assessment-of-new-parp-inhibitor-talazoparib-using-peer-reviewed-article-DDDT

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https://www.dovepress.com/metabolic-stability-assessment-of-new-parp-inhibitor-talazoparib-using-peer-reviewed-article-DDDT

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