Polymorphisms within methotrexate pathway genes: Relationship between plasma methotrexate levels, toxicity experienced and outcome in pediatric acute lymphoblastic leukemia

Polymorphisms within methotrexate pathway genes: Relationship between plasma methotrexate levels, toxicity experienced and outcome in pediatric acute lymphoblastic leukemia

<em><strong>Objective(s):</strong></em> The current study aimed to investigate the relationship of genetic polymorphism and plasma methotrexate (MTX) levels, toxicity experience and event free survival (EFS) in pediatric acute lymphoblastic leukemia (ALL). <br /><em&...

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Bibliographic Details
Main Authors: Mohammad Ali Esmaili, Ahmad Kazemi, Mohammad Faranoush, Hakan Mellstedt, Farhad Zaker, Majid safa, Narjes Mehrvar, Mohammad Reza Rezvany
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2020-06-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
abcb1
abcg2
genetic polymorphism
genotype
methotrexate
mthfr
pediatric acute lymphoblastic- leukemia
slc19a1
Online Access:http://ijbms.mums.ac.ir/article_15480_24fdc6bf4ec226c098f2413443746b05.pdf

Internet

http://ijbms.mums.ac.ir/article_15480_24fdc6bf4ec226c098f2413443746b05.pdf

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