Research status of genes related to primary gout and hyperuricemia
Existing studies have shown that primary gout and hyperuricemia are a group of polygenetic hereditary diseases, which are the results of the combination of genetic and environmental factors. However, the study on the genetic susceptibility of gout and hyperuricemia is not yet complete and it is...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2019-08-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201916/16 |
| Summary: | Existing studies have shown that primary gout and hyperuricemia are a group
of polygenetic hereditary diseases, which are the results of the combination of genetic
and environmental factors. However, the study on the genetic susceptibility of gout and
hyperuricemia is not yet complete and it is not yet possible to predict which populations are
susceptible to gout and hyperuricemia. Genome-wide association study (GWAS), a method
developed in recent years, is used to identify susceptibility genes for complex disease
pathogenesis. Through screening patients and the normal control, and combined with computer
technology and statistical analysis, genome-wide variation can be used to identify minor gene
and its interaction with related diseases. In our study, we summarized and classified uric acid
related genes discovered in recent years, so as to provide a basis for further understanding of
the molecular mechanism of gout and hyperuricemia, and provide a beneficial reference for
further study on the etiology of gout and hyperuricemia. |
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| ISSN: | 1007-1237 1007-1237 |