Molecular analysis of the eighteen most frequent mutations in the BRCA1 gene in 63 Chilean breast cancer families

Molecular analysis of the eighteen most frequent mutations in the BRCA1 gene in 63 Chilean breast cancer families

BRCA1 gene mutations account for nearly all families with multiple cases of both early onset breast and/or ovarian cancer and about 30% of hereditary breast cancer. Although to date more than 1,237 distinct mutations, polymorphisms, and variants have been described, several mutations have been found...

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Bibliographic Details
Main Authors: LILIAN JARA, SANDRA AMPUERO, EUDOCIA SANTIBÁÑEZ, LORENA SECCIA, JUAN RODRÍGUEZ, MARIO BUSTAMANTE, GUILLERMO LAY-SON, JOSÉ MANUEL OJEDA, JOSÉ MIGUEL REYES, RAFAEL BLANCO
Format: Article
Language:English
Published: BMC 2004-01-01
Series:Biological Research
Subjects:
BRCA1 gene
frequent mutations
polymorphism
4185delCAAG
new mutation
Chilean population
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000300011

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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000300011

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