N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularization

N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularization

Proteoglycans are glycosylated proteins that play a number of structural and signalling functions. Here, Corti, Wang et al. show that the N-terminal sequence of proteoglycan Syndecan-2 selectively increases 6-O sulfation of its heparan sulfate chains, and that this promotes formation of a ternary Sd...

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Bibliographic Details
Main Authors: Federico Corti, Yingdi Wang, John M. Rhodes, Deepak Atri, Stephanie Archer-Hartmann, Jiasheng Zhang, Zhen W. Zhuang, Dongying Chen, Tianyun Wang, Zhirui Wang, Parastoo Azadi, Michael Simons
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09605-z

Internet

https://doi.org/10.1038/s41467-019-09605-z

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