CD169+ lymph node macrophages have protective functions in mouse breast cancer metastasis

CD169+ lymph node macrophages have protective functions in mouse breast cancer metastasis

Summary: Although the contribution of macrophages to metastasis is widely studied in primary tumors, the involvement of macrophages in tumor-draining lymph nodes (LNs) in this process is less clear. We find CD169+ macrophages as the predominant macrophage subtype in naive LNs, which undergo prolifer...

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Bibliographic Details
Main Authors: Carlotta Tacconi, Catharina D. Commerford, Lothar C. Dieterich, Simon Schwager, Yuliang He, Kristian Ikenberg, Ekaterina Friebel, Burkhard Becher, Sònia Tugues, Michael Detmar
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
lymph node macrophages
tumor-associated macrophages
distant organ metastasis
tumor-draining lymph node
breast cancer metastasis
CD169+ macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721003077

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http://www.sciencedirect.com/science/article/pii/S2211124721003077

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