Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome
Background and Purpose: Aspergillus species are implicated as the etiology of approximately 26% of endocarditis cases. Central nervous system aspergillosis is a life-threatening condition that has a mortality rate of 80%. Case report: Herein, we report a four– year- old female who was admitted to th...
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Mazandaran University of Medical Sciences
2020-12-01
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doaj-4e2f446428b64cb59450df7091e09b7d2021-07-14T06:22:34ZengMazandaran University of Medical SciencesCurrent Medical Mycology2423-34392423-34202020-12-0164707410.18502/cmm.6.4.5441119577Aspergillus flavus endocarditis and meningitis in a child with marfan syndromeAzam Fattahi0Shirin Sayyahfar1Ensieh Lotfali2Reza Ghasemi3Hojjat Mortezaeian4Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, IranDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Ali Asghar Children Hospital, Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, IranDepartment of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranRajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, IranBackground and Purpose: Aspergillus species are implicated as the etiology of approximately 26% of endocarditis cases. Central nervous system aspergillosis is a life-threatening condition that has a mortality rate of 80%. Case report: Herein, we report a four– year- old female who was admitted to the pediatric infectious ward due to a fever of unknown origin in January 2020. She was a known case of Marfan syndrome with a family history of this syndrome in her mother. The species was identified using (PCR) and the antifungal susceptibility test was performed using four antifungal agents based on the Clinical and Laboratory Standards Institute M38 3rd edition. Fluconazole-resistant Aspergillus flavus was identified to be responsible for endocarditis and meningitis as well as fever of unknown origin. Conclusion: The clinicians should be aware and consider fungal endocarditis in blood culture-negative endocarditis even in patients with no significant risk factor when antibiotic therapy fails.http://cmm.mazums.ac.ir/article_119577_5402300813d331cf3e8c10885e5384f1.pdfaspergillus flavusendocarditisfluconazolemeningitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Azam Fattahi Shirin Sayyahfar Ensieh Lotfali Reza Ghasemi Hojjat Mortezaeian |
spellingShingle |
Azam Fattahi Shirin Sayyahfar Ensieh Lotfali Reza Ghasemi Hojjat Mortezaeian Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome Current Medical Mycology aspergillus flavus endocarditis fluconazole meningitis |
author_facet |
Azam Fattahi Shirin Sayyahfar Ensieh Lotfali Reza Ghasemi Hojjat Mortezaeian |
author_sort |
Azam Fattahi |
title |
Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome |
title_short |
Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome |
title_full |
Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome |
title_fullStr |
Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome |
title_full_unstemmed |
Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome |
title_sort |
aspergillus flavus endocarditis and meningitis in a child with marfan syndrome |
publisher |
Mazandaran University of Medical Sciences |
series |
Current Medical Mycology |
issn |
2423-3439 2423-3420 |
publishDate |
2020-12-01 |
description |
Background and Purpose: Aspergillus species are implicated as the etiology of approximately 26% of endocarditis cases. Central nervous system aspergillosis is a life-threatening condition that has a mortality rate of 80%. Case report: Herein, we report a four– year- old female who was admitted to the pediatric infectious ward due to a fever of unknown origin in January 2020. She was a known case of Marfan syndrome with a family history of this syndrome in her mother. The species was identified using (PCR) and the antifungal susceptibility test was performed using four antifungal agents based on the Clinical and Laboratory Standards Institute M38 3rd edition. Fluconazole-resistant Aspergillus flavus was identified to be responsible for endocarditis and meningitis as well as fever of unknown origin. Conclusion: The clinicians should be aware and consider fungal endocarditis in blood culture-negative endocarditis even in patients with no significant risk factor when antibiotic therapy fails. |
topic |
aspergillus flavus endocarditis fluconazole meningitis |
url |
http://cmm.mazums.ac.ir/article_119577_5402300813d331cf3e8c10885e5384f1.pdf |
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