Obesity and lipid stress inhibit carnitine acetyltransferase activity[S]

Obesity and lipid stress inhibit carnitine acetyltransferase activity[S]

Carnitine acetyltransferase (CrAT) is a mitochondrial matrix enzyme that catalyzes the interconversion of acetyl-CoA and acetylcarnitine. Emerging evidence suggests that this enzyme functions as a positive regulator of total body glucose tolerance and muscle activity of pyruvate dehydrogenase (PDH),...

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Bibliographic Details
Main Authors: Sarah E. Seiler, Ola J. Martin, Robert C. Noland, Dorothy H. Slentz, Karen L. DeBalsi, Olga R. Ilkayeva, Jie An, Christopher B. Newgard, Timothy R. Koves, Deborah M. Muoio
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Journal of Lipid Research
Subjects:
acetyl-coenzyme A
acylcarnitines
lipid metabolism
mitochondria
muscle
diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520376537

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http://www.sciencedirect.com/science/article/pii/S0022227520376537

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