Histone deacetylase inhibition reduces cardiac Connexin43 expression and gap junction communication

Histone deacetylase inhibition reduces cardiac Connexin43 expression and gap junction communication

Histone deactylase (HDAC) inhibitors are being investigated as novel therapies for cancer, inflammation, neurodegeneration, and heart failure. The effects of HDAC inhibitors on the functional expression of cardiac gap junctions (GJ) are essentially unknown. The purpose of this study was to determine...

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Bibliographic Details
Main Authors: Qin eXu, Xianming eLin, Laura eAndrews, Dakshesh ePatel, Paul D Lampe, Richard David Veenstra
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Pharmacology
Subjects:
Gap Junctions
Phosphorylation
connexin43
connexin40
Trichostatin A
vorinostat
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00044/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00044/full

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