| Summary: | Oral microbiome plays an important part on oral health and endogenous bacteria and fungi should not be eradicated. However, their proliferation must be controlled by oral hygiene care. In vitro, <i>Solidago virgaurea</i> ssp. <i>virgaurea</i> L. (SV) plant extract inhibits the adherence and hyphal formation of a fungus, <i>Candida albicans</i>. It reduces the biomass of <i>Candida</i>-bacterial biofilms but not fungal or bacterial growth. Unlike chemical antiseptics, like triclosan and chlorhexidine for instance, SV is a plant extract easily biodegradable. The purpose of this study was to assess the in vivo effectiveness of SV extract in reducing oral biomass. A randomized, double-blind clinical study, with dental plaque evaluation designed to assess the effectiveness of a fluorinated toothpaste containing SV (Bucovia™, Givaudan, Vernier, Switzerland) was conducted. Sixty-six subjects (SV group <i>n</i> = 33 vs. control <i>n</i> = 33) brushed their teeth twice a day for a 4-week period. Supragingival dental plaque was sampled. Total bacterial load (broad spectral bacterial quantitative Polymerase Chain Reaction (qPCR)), <i>C. albicans</i> and seven bacterial species were quantified by qPCR. In the Intervention group, there was a decrease of Total bacterial load (ΔD0D28 <i>p</i> = 0.005 and ΔD14D28 <i>p</i> = 0.026), <i>Streptococcus mutans</i> (ΔD0D14 <i>p </i>= 0.024) and <i>C. albicans</i> (ΔD0D28 <i>p</i> = 0.022). In the Control group Total bacterial load tended to decrease from baseline to day 28 (ΔD0D28 <i>p</i> = 0.062 and ΔD14D28 <i>p</i> = 0.009). Plaque Index and Gingival Index improved in both groups.
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