Loss of miR-101-3p Promotes Transmigration of Metastatic Breast Cancer Cells through the Brain Endothelium by Inducing COX-2/MMP1 Signaling

Loss of miR-101-3p Promotes Transmigration of Metastatic Breast Cancer Cells through the Brain Endothelium by Inducing COX-2/MMP1 Signaling

Brain metastases represent one of the incurable end stages in breast cancer (BC). Developing effective or preventive treatments is hampered by a lack of knowledge on the molecular mechanisms driving brain metastasis. Transmigration of BC cells through the brain endothelium is a key event in the path...

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Bibliographic Details
Main Authors: Rania Harati, Mohammad G. Mohammad, Abdelaziz Tlili, Raafat A. El-Awady, Rifat Hamoudi
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceuticals
Subjects:
micro-RNA
breast cancer
brain metastasis
blood–brain barrier
Online Access:https://www.mdpi.com/1424-8247/13/7/144

Internet

https://www.mdpi.com/1424-8247/13/7/144

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