The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis

Background: Gallstone disease and chronic calculous cholecystitis are the most prevalent gastro-enterological diseases requiring a surgical treatment. This disease occupies a special place in the pathology of the hepato-bilio-pancreatic area, which is important for the etiological diagnosis as well...

Full description

Bibliographic Details
Main Authors: Viorel Moraru, Petru Bujor, Galina Pavliuc, Sergiu Bujor
Format: Article
Language:English
Published: Scientific Medical Association of Moldova 2018-10-01
Series:The Moldovan Medical Journal
Subjects:
Online Access:http://moldmedjournal.md/wp-content/uploads/2018/11/moldmedjournal-2018-61-3-moraru-et-al-full-article.pdf
id doaj-50b9a856371d4d17838d966ab3a7251c
record_format Article
spelling doaj-50b9a856371d4d17838d966ab3a7251c2020-11-25T02:32:26ZengScientific Medical Association of MoldovaThe Moldovan Medical Journal2537-63732537-63812018-10-01613576210.5281/zenodo.1456885The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasisViorel Moraru0Petru Bujor1Galina Pavliuc2Sergiu Bujor3Department of Surgery No 2, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaDepartment of Surgery No 2, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaDepartment of Surgery No 2, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaLaboratory of Liver Surgery, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaBackground: Gallstone disease and chronic calculous cholecystitis are the most prevalent gastro-enterological diseases requiring a surgical treatment. This disease occupies a special place in the pathology of the hepato-bilio-pancreatic area, which is important for the etiological diagnosis as well as for the resonance and the complex impact on the function of the adjacent organs. Besides, gallstone disease can result in serious outcomes, such as acute gallstone pancreatitis and gallbladder cancer. This article analyzes the clinico- morphological characteristics of gallbladder stones. At the same time, the role of duodenal dysmotility in the ethiopathogenesis of cholestasis was reevaluated through the contemplation of the contemporary concepts of lithogenesis. Conclusions: The pathogenesis of gallstone disease is suggested to be multifactorial and probably develops from complex interactions between many genetic and environmental factors and the state of adjacent organs. Based on its anatomical and physiological features, the duodenum is a completely unique crossroads where the digestive pathways of the stomach, liver and pancreas meet. The sealing functionality of these organs allows them to be cataloged as an integral system, and the duodenum due to its specific role exerts ”the pituitary function” of the gastrointestinal tract. Therefore, any disruption of the duodenum activity may not be etiopathogenetically reflected on the hepatobiliary-pancreatic disease, and biliary cholelithiasis is no exception in this regard. The achievement in the study of the pathophysiology of bile stones formation and the pathogenesis of gallstone disease can help to improve the complex medico-surgical treatment of this category of patients.http://moldmedjournal.md/wp-content/uploads/2018/11/moldmedjournal-2018-61-3-moraru-et-al-full-article.pdfcholelithiasisduodenal dysmotilitygallstone
collection DOAJ
language English
format Article
sources DOAJ
author Viorel Moraru
Petru Bujor
Galina Pavliuc
Sergiu Bujor
spellingShingle Viorel Moraru
Petru Bujor
Galina Pavliuc
Sergiu Bujor
The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis
The Moldovan Medical Journal
cholelithiasis
duodenal dysmotility
gallstone
author_facet Viorel Moraru
Petru Bujor
Galina Pavliuc
Sergiu Bujor
author_sort Viorel Moraru
title The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis
title_short The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis
title_full The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis
title_fullStr The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis
title_full_unstemmed The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis
title_sort reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis
publisher Scientific Medical Association of Moldova
series The Moldovan Medical Journal
issn 2537-6373
2537-6381
publishDate 2018-10-01
description Background: Gallstone disease and chronic calculous cholecystitis are the most prevalent gastro-enterological diseases requiring a surgical treatment. This disease occupies a special place in the pathology of the hepato-bilio-pancreatic area, which is important for the etiological diagnosis as well as for the resonance and the complex impact on the function of the adjacent organs. Besides, gallstone disease can result in serious outcomes, such as acute gallstone pancreatitis and gallbladder cancer. This article analyzes the clinico- morphological characteristics of gallbladder stones. At the same time, the role of duodenal dysmotility in the ethiopathogenesis of cholestasis was reevaluated through the contemplation of the contemporary concepts of lithogenesis. Conclusions: The pathogenesis of gallstone disease is suggested to be multifactorial and probably develops from complex interactions between many genetic and environmental factors and the state of adjacent organs. Based on its anatomical and physiological features, the duodenum is a completely unique crossroads where the digestive pathways of the stomach, liver and pancreas meet. The sealing functionality of these organs allows them to be cataloged as an integral system, and the duodenum due to its specific role exerts ”the pituitary function” of the gastrointestinal tract. Therefore, any disruption of the duodenum activity may not be etiopathogenetically reflected on the hepatobiliary-pancreatic disease, and biliary cholelithiasis is no exception in this regard. The achievement in the study of the pathophysiology of bile stones formation and the pathogenesis of gallstone disease can help to improve the complex medico-surgical treatment of this category of patients.
topic cholelithiasis
duodenal dysmotility
gallstone
url http://moldmedjournal.md/wp-content/uploads/2018/11/moldmedjournal-2018-61-3-moraru-et-al-full-article.pdf
work_keys_str_mv AT viorelmoraru thereevaluationoftheroleofduodenaldysmotilityintheetiopathogenesisofvesicularcholelithiasis
AT petrubujor thereevaluationoftheroleofduodenaldysmotilityintheetiopathogenesisofvesicularcholelithiasis
AT galinapavliuc thereevaluationoftheroleofduodenaldysmotilityintheetiopathogenesisofvesicularcholelithiasis
AT sergiubujor thereevaluationoftheroleofduodenaldysmotilityintheetiopathogenesisofvesicularcholelithiasis
AT viorelmoraru reevaluationoftheroleofduodenaldysmotilityintheetiopathogenesisofvesicularcholelithiasis
AT petrubujor reevaluationoftheroleofduodenaldysmotilityintheetiopathogenesisofvesicularcholelithiasis
AT galinapavliuc reevaluationoftheroleofduodenaldysmotilityintheetiopathogenesisofvesicularcholelithiasis
AT sergiubujor reevaluationoftheroleofduodenaldysmotilityintheetiopathogenesisofvesicularcholelithiasis
_version_ 1724819264652705792