The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis
Background: Gallstone disease and chronic calculous cholecystitis are the most prevalent gastro-enterological diseases requiring a surgical treatment. This disease occupies a special place in the pathology of the hepato-bilio-pancreatic area, which is important for the etiological diagnosis as well...
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Scientific Medical Association of Moldova
2018-10-01
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doaj-50b9a856371d4d17838d966ab3a7251c2020-11-25T02:32:26ZengScientific Medical Association of MoldovaThe Moldovan Medical Journal2537-63732537-63812018-10-01613576210.5281/zenodo.1456885The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasisViorel Moraru0Petru Bujor1Galina Pavliuc2Sergiu Bujor3Department of Surgery No 2, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaDepartment of Surgery No 2, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaDepartment of Surgery No 2, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaLaboratory of Liver Surgery, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaBackground: Gallstone disease and chronic calculous cholecystitis are the most prevalent gastro-enterological diseases requiring a surgical treatment. This disease occupies a special place in the pathology of the hepato-bilio-pancreatic area, which is important for the etiological diagnosis as well as for the resonance and the complex impact on the function of the adjacent organs. Besides, gallstone disease can result in serious outcomes, such as acute gallstone pancreatitis and gallbladder cancer. This article analyzes the clinico- morphological characteristics of gallbladder stones. At the same time, the role of duodenal dysmotility in the ethiopathogenesis of cholestasis was reevaluated through the contemplation of the contemporary concepts of lithogenesis. Conclusions: The pathogenesis of gallstone disease is suggested to be multifactorial and probably develops from complex interactions between many genetic and environmental factors and the state of adjacent organs. Based on its anatomical and physiological features, the duodenum is a completely unique crossroads where the digestive pathways of the stomach, liver and pancreas meet. The sealing functionality of these organs allows them to be cataloged as an integral system, and the duodenum due to its specific role exerts ”the pituitary function” of the gastrointestinal tract. Therefore, any disruption of the duodenum activity may not be etiopathogenetically reflected on the hepatobiliary-pancreatic disease, and biliary cholelithiasis is no exception in this regard. The achievement in the study of the pathophysiology of bile stones formation and the pathogenesis of gallstone disease can help to improve the complex medico-surgical treatment of this category of patients.http://moldmedjournal.md/wp-content/uploads/2018/11/moldmedjournal-2018-61-3-moraru-et-al-full-article.pdfcholelithiasisduodenal dysmotilitygallstone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Viorel Moraru Petru Bujor Galina Pavliuc Sergiu Bujor |
spellingShingle |
Viorel Moraru Petru Bujor Galina Pavliuc Sergiu Bujor The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis The Moldovan Medical Journal cholelithiasis duodenal dysmotility gallstone |
author_facet |
Viorel Moraru Petru Bujor Galina Pavliuc Sergiu Bujor |
author_sort |
Viorel Moraru |
title |
The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis |
title_short |
The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis |
title_full |
The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis |
title_fullStr |
The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis |
title_full_unstemmed |
The reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis |
title_sort |
reevaluation of the role of duodenal dysmotility in the etiopathogenesis of vesicular cholelithiasis |
publisher |
Scientific Medical Association of Moldova |
series |
The Moldovan Medical Journal |
issn |
2537-6373 2537-6381 |
publishDate |
2018-10-01 |
description |
Background: Gallstone disease and chronic calculous cholecystitis are the most prevalent gastro-enterological diseases requiring a surgical treatment. This disease occupies a special place in the pathology of the hepato-bilio-pancreatic area, which is important for the etiological diagnosis as well as for the resonance and the complex impact on the function of the adjacent organs. Besides, gallstone disease can result in serious outcomes, such as acute gallstone pancreatitis and gallbladder cancer. This article analyzes the clinico- morphological characteristics of gallbladder stones. At the same time, the role of duodenal dysmotility in the ethiopathogenesis of cholestasis was reevaluated through the contemplation of the contemporary concepts of lithogenesis. Conclusions: The pathogenesis of gallstone disease is suggested to be multifactorial and probably develops from complex interactions between many genetic and environmental factors and the state of adjacent organs. Based on its anatomical and physiological features, the duodenum is a completely unique crossroads where the digestive pathways of the stomach, liver and pancreas meet. The sealing functionality of these organs allows them to be cataloged as an integral system, and the duodenum due to its specific role exerts ”the pituitary function” of the gastrointestinal tract. Therefore, any disruption of the duodenum activity may not be etiopathogenetically reflected on the hepatobiliary-pancreatic disease, and biliary cholelithiasis is no exception in this regard. The achievement in the study of the pathophysiology of bile stones formation and the pathogenesis of gallstone disease can help to improve the complex medico-surgical treatment of this category of patients. |
topic |
cholelithiasis duodenal dysmotility gallstone |
url |
http://moldmedjournal.md/wp-content/uploads/2018/11/moldmedjournal-2018-61-3-moraru-et-al-full-article.pdf |
work_keys_str_mv |
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