Substrate Specificities and Inhibition Pattern of the Solute Carrier Family 10 Members NTCP, ASBT and SOAT

Substrate Specificities and Inhibition Pattern of the Solute Carrier Family 10 Members NTCP, ASBT and SOAT

Three carriers of the solute carrier family SLC10 have been functionally characterized so far. Na+/taurocholate cotransporting polypeptide NTCP is a hepatic bile acid transporter and the cellular entry receptor for the hepatitis B and D viruses. Its intestinal counterpart, apical sodium-dependent bi...

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Bibliographic Details
Main Authors: Gary Grosser, Simon Franz Müller, Michael Kirstgen, Barbara Döring, Joachim Geyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
SLC10A1
SLC10A2
substrate specificity
drug target
NTCP
transport inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.689757/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.689757/full

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