Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations

Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations

Mutations in the human CSF1R gene have been associated with dominant and recessive forms of neurodegenerative disease. Here we describe the impacts of Csf1r mutation in the rat on development of the brain. Diffusion imaging indicated small reductions in major fiber tracts that may be associated in p...

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Bibliographic Details
Main Authors: Omkar L. Patkar, Melanie Caruso, Ngari Teakle, Sahar Keshvari, Stephen J. Bush, Clare Pridans, Arnauld Belmer, Kim M. Summers, Katharine M. Irvine, David A. Hume
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Neurobiology of Disease
Subjects:
Microglia
CSF1R
Knockout
Rat
Leukoencephalopathy
RNA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000176

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http://www.sciencedirect.com/science/article/pii/S0969996121000176

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