Admixture mapping identifies genetic regions associated with blood pressure phenotypes in African Americans.
Hypertension occurs at a higher rate in African Americans than in European Americans. Based on the assumption that causal variants are more frequently found on DNA segments inherited from the ancestral population with higher disease risk, we employed admixture mapping to identify genetic loci with e...
Main Authors: | Zhi Liu, Daniel Shriner, Nancy F Hansen, Charles N Rotimi, James C Mullikin, NISC Comparative Sequencing Program |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0232048 |
Similar Items
-
Development of admixture mapping panels for African Americans from commercial high-density SNP arrays
by: Dunston Georgia M, et al.
Published: (2010-07-01) -
Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X.
by: Ching-Yu Cheng, et al.
Published: (2009-05-01) -
Alternative Isoform Analysis of Ttc8 Expression in the Rat Pineal Gland Using a Multi-Platform Sequencing Approach Reveals Neural Regulation.
by: Stephen W Hartley, et al.
Published: (2016-01-01) -
Admixture mapping of African-American women in the AMBER Consortium identifies new loci for breast cancer and estrogen-receptor subtypes
by: Edward Antonio Ruiz-Narvaez, et al.
Published: (2016-09-01) -
Phenotypic variance explained by local ancestry in admixed African Americans
by: Daniel eShriner, et al.
Published: (2015-10-01)