Why tyrosine kinase inhibitor resistance is common in advanced gastrointestinal stromal tumors [v1; ref status: indexed, http://f1000r.es/1ac]

Background: Most patients with advanced gastrointestinal stromal tumors (GIST) develop drug resistance to tyrosine kinase inhibitors (TKIs) within two years of starting therapy, whereas most chronic myeloid leukemia (CML) patients in chronic phase still exhibit disease control after a decade on ther...

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Bibliographic Details
Main Authors: Cristian Tomasetti, George D Demetri, Giovanni Parmigiani
Format: Article
Language:English
Published: F1000 Research Ltd 2013-07-01
Series:F1000Research
Subjects:
Online Access:http://f1000research.com/articles/2-152/v1