Design, synthesis and evaluation of novel 3,5-disubstituted benzamide derivatives as allosteric glucokinase activators

Design, synthesis and evaluation of novel 3,5-disubstituted benzamide derivatives as allosteric glucokinase activators

Abstract Glucokinase (GK) is the key enzyme expressed in β-cells of pancreas and liver hepatocytes and helps in the maintenance of blood glucose levels in normal range. Activators of GK are the novel category of drug candidates which activate GK enzyme allosterically and show their antidiabetic acti...

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Bibliographic Details
Main Authors: Ajmer Singh Grewal, Rajeev Kharb, Deo Nandan Prasad, Jagdeep Singh Dua, Viney Lather
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Chemistry
Subjects:
Antidiabetic activity
Benzamides
Glucokinase
GK activators
In silico
In vitro assay
Online Access:http://link.springer.com/article/10.1186/s13065-019-0532-8

Internet

http://link.springer.com/article/10.1186/s13065-019-0532-8

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