A novel SPAST gene mutation identified in a Chinese family with hereditary spastic paraplegia

A novel SPAST gene mutation identified in a Chinese family with hereditary spastic paraplegia

Abstract Background Hereditary spastic paraplegia is a heterogeneous group of clinically and genetically neurodegenerative diseases characterized by progressive gait disorder. Hereditary spastic paraplegia can be inherited in various ways, and all modes of inheritance are associated with multiple ge...

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Bibliographic Details
Main Authors: Weiwei Yu, Haiqiang Jin, Jianwen Deng, Ding Nan, Yining Huang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Medical Genetics
Subjects:
Hereditary spastic paraplegia
Gait disorder
Whole exome sequencing
SPAST gene
In-frame deletion
Online Access:http://link.springer.com/article/10.1186/s12881-020-01053-7

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http://link.springer.com/article/10.1186/s12881-020-01053-7

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